Publications by authors named "G Osborn"
Article Synopsis
- * Researchers used PET imaging to study the behavior of NK cells that were tagged with a radiolabel (Zr) and how their accumulation in breast tumors was affected by trastuzumab treatment in mouse models.
- * Results showed that the tagged NK cells successfully migrated to HER2-positive tumors, with enhanced accumulation noted when combined with trastuzumab treatment, while also retaining essential functions necessary for their immune response capabilities.
Introduction: Between 2000 and 2015, significant gains were recorded in reducing the global burden of malaria due to enhanced global collaboration and increased funding. However, progress has stagnated post-2015, and the COVID-19 pandemic seems to have reversed some of these gains, necessitating a critical reevaluation of interventions. This paper aims to analyze the setbacks and offer recommendations for advancement in malaria control and prevention in sub-Saharan Africa.
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- Despite advancements in immunotherapies for melanoma, many patients still don't benefit due to current treatments mainly targeting T-cells rather than the more prevalent macrophages in the tumor environment.
- Macrophages have a dual role: they can activate the immune response and kill cancer cells, but they can also aid in tumor growth and spread depending on their interaction with the tumor microenvironment.
- A thorough understanding of macrophages' roles and interactions in melanoma, along with novel therapies aimed at them, is crucial for enhancing treatment outcomes for melanoma patients.
Background: Survival rates for ovarian cancer remain poor, and monitoring and prediction of therapeutic response may benefit from additional markers. Ovarian cancers frequently overexpress Folate Receptor alpha (FRα) and the soluble receptor (sFRα) is measurable in blood. Here we investigated sFRα as a potential biomarker.
View Article and Find Full Text PDFCD4+CD25+Foxp3+ Tregs are known to acquire tissue-specific features and exert cytoprotective and regenerative functions. The extent to which this applies to liver-resident Tregs is unknown. In this study, we aimed to explore the phenotypic and functional characteristics of adult murine liver resident Tregs during homeostasis.
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