Publications by authors named "G Orvoen"

Introduction: Falling is a public health problem that could be prevented by screening at-risk populations. Several tools exist, some of which assess lower urinary tract symptoms (LUTS). Our aim was to examine knowledge and practice regarding the assessment of LUTS when screening for fall risk in older people.

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Background & Aims: Predicting the risk of early limiting toxicity (ELT) is major challenge for the clinician seeking an effective, safe treatment for older patients with cancer. The Cancer and Aging Research Group (CARG) and CRASH (Chemotherapy Risk Assessment Scale for High-Age Patients) toxicity scores were designed to predict chemotherapy-related toxicity. Elevated resting energy expenditure (REE) may predispose to cachexia and increase ELT and mortality in older patients with cancer.

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Background: The dynamics of SARS-CoV-2 alpha variant shedding and immune responses at the nasal mucosa remain poorly characterised.

Methods: We measured infectious viral release, antibodies and cytokines in 426 PCR+ nasopharyngeal swabs from individuals harboring non-alpha or alpha variants.

Findings: With both lineages, viral titers were variable, ranging from 0 to >10 infectious units.

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Background: In older patients with cancer, depression is difficult to assess because of its heterogeneous clinical expression. The 4-item version of the Geriatric Depression Scale (GDS-4) is quick and easy to administer but has not been validated in this population. The present study was designed to test the diagnostic performance of the GDS-4 in a French cohort of older patients with cancer before treatment.

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Article Synopsis
  • The study aimed to evaluate the safety of the direct oral anticoagulant rivaroxaban compared to vitamin K antagonists (VKAs) in geriatric patients (aged ≥80) with non-valvular atrial fibrillation (AF).
  • Using data from 33 geriatric centers, researchers followed 908 patients on VKAs and 995 on rivaroxaban for up to 12 months to compare bleeding risks and other health outcomes.
  • Results showed that rivaroxaban users experienced significantly lower risks of major and intracerebral bleeding compared to VKA users, suggesting it may be a safer option for older adults in preventing strokes.
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