Publications by authors named "G Oroszlan"
Article Synopsis
- - DNA polymerases are key targets for drugs, but there's still a lack of understanding about how their changing shapes affect drug resistance.
- - Cryoelectron microscopy (cryo-EM) was used to capture the structure of herpes simplex virus polymerase in various shapes while bound to DNA and interacting with antiviral drugs.
- - Findings suggest that drug resistance can occur through changes in the polymerase's shape, rather than through direct effects on how drugs bind, offering insights into how some antivirals can better target their enzyme.
Complement factor D (FD) is a serine protease present predominantly in the active form in circulation. It is synthesized as a zymogen (pro-FD), but it is continuously converted to FD by circulating active MASP-3. FD is a unique, self-inhibited protease.
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- Citrullination is the process where arginine is converted to citrulline by protein arginine deiminases (PADs), which is linked to various cancers and autoimmune diseases.
- Human cytomegalovirus (HCMV) infection causes this citrullination in human fibroblasts, enhancing the virus's ability to survive and replicate by modifying host proteins.
- The study finds that the interferon-inducible protein IFIT1 is significantly affected by citrullination during HCMV infection, suggesting that this modification helps the virus evade the host's antiviral responses.
Factor D (FD) is an essential element of the alternative pathway of the complement system, and it circulates predominantly in cleaved, activated form in the blood. In resting blood, mannose-binding lectin-associated serine protease 3 (MASP-3) is the exclusive activator of pro-FD. Similarly to FD, MASP-3 also circulates mainly in the active form.
View Article and Find Full Text PDFEcotin is a serine protease inhibitor produced by hundreds of microbial species, including pathogens. Here we show, that ecotin orthologs from Escherichia coli, Yersinia pestis, Pseudomonas aeruginosa and Leishmania major are potent inhibitors of MASP-1 and MASP-2, the two key activator proteases of the complement lectin pathway. Factor D is the key activator protease of another complement activation route, the alternative pathway.
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