Publications by authors named "G Orlandi"
Background And Objectives: The benefit of mechanical thrombectomy (MT) in patients with acute ischemic stroke (AIS) with basilar artery occlusion (BAO) and a baseline National Institute of Health Stroke Scale (NIHSS) score <10 is unclear because this subpopulation has been substantially excluded from large clinical trials. The aim of our study was to determine whether MT ± IV thrombolysis (IVT) improves functional outcomes compared with IVT alone in patients with BAO and a NIHSS score <10.
Methods: We emulated a hypothetical trial including adult patients with BAO, a baseline NIHSS score <10, and prestroke modified Rankin scale (mRS) scores 0-2, comparing MT (±IVT) with IVT alone.
Galectin-3 (Gal-3) is a pleiotropic lectin produced by most cell types, which regulates multiple cellular processes in various tissues. In bone, depending on its cellular localization, Gal-3 has a dual and opposite role. If, on the one hand, intracellular Gal-3 promotes bone formation, on the other, its circulating form affects bone remodeling, antagonizing osteoblast differentiation and increasing osteoclast activity.
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- This study investigates the early diagnosis of preeclampsia (PE) by analyzing biochemical changes and immune system activity in pregnant women.
- Researchers compared 30 women divided into three groups: healthy pregnant women, those with early preeclampsia, and those with late preeclampsia, focusing on various immune markers and lipid profiles.
- Results showed notable increases in immune markers IL-6 and IL-8 in early preeclampsia cases, indicating heightened immune activity, while a decrease in PCSK9 gene expression was observed in early preeclampsia, suggesting potential implications for placental hormone synthesis.
Problem: Knowledge about physical activity in pregnancy is limited compared to general population and several approaches have been used to evaluate duration and intensity of physical activity during pregnancy.
Background: Although physical activity can contribute to maternal and fetal well-being, more than half of women stopped their physical activity because of pregnancy.
Aim: To evaluate the adherence to physical activity of low-risk pregnant women by adapting an Italian version of the PPAQ.