Publications by authors named "G Olaso-Gonzalez"
Osteoporosis is a chronic disease that is characterized by a loss of bone density, which mainly affects the microstructure of the bones due to a decrease in bone mass, thereby making them more fragile and susceptible to fractures. Osteoporosis is currently considered one of the pandemics of the 21st century, affecting around 200 million people. Its most serious consequence is an increased risk of bone fractures, thus making osteoporosis a major cause of disability and even premature death in the elderly.
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- Lifelong function declines due to aging, chronic diseases, and lifestyle factors, leading to issues like frailty and disability, especially impacting skeletal muscle through conditions like sarcopenia.
- The manuscript explores the age-related changes in skeletal muscle, discussing how these changes affect quality of life and independence in older adults.
- It highlights exercise as a key intervention for reversing frailty, examines various training programs, the nutritional factors influencing muscle health, and discusses genetic interventions aimed at enhancing resilience against muscle aging.
Article Synopsis
- Exercise is important for staying healthy and can help prevent diseases as we age.
- When we exercise, our bodies learn to handle stress better, which can lead to positive long-term changes.
- Scientists are studying how our muscles remember exercise to help athletes train better and help people recover from injuries more effectively.
Mice models of Alzheimer's disease (APP/PS1) typically experience cognitive decline with age. G6PD overexpressing mice (G6PD-Tg) exhibit better protection from age-associated functional decline including improvements in metabolic and muscle functions as well as reduced frailty compared to their wild-type counterparts. Importantly G6PD-Tg mice show diminished accumulation of DNA oxidation in the brain at different ages in both males and females.
View Article and Find Full Text PDFMost of the studies on physical exercise in older adults have been conducted through randomized clinical trials performed under tight experimental conditions. Data regarding Real-Life physical exercise intervention programs in older adults with different conditions and in different settings, are lacking. This is an interventional, prospective and pragmatic Real-Life study in which fifty sedentary and frail individuals were enrolled.
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