High-resolution image cytometry on smears of normal oral mucosa: a possible approach for the early detection of laryngopharyngeal cancers.

Background: The purpose of this study was to investigate the possibility of identifying laryngopharyngeal cancers by nuclear chromatin texture feature analysis of cell nuclei from mucosal scrapings obtained from clinically and cytologically noncancerous areas of the soft palate in patients with cancer.

Methods: The collective consisted of 68 controls and 77 cases of laryngopharyngeal carcinomas. After Feulgen staining, 3000 cell nuclei were automatically measured using a high-resolution image analyser (CytoSavant Oncometrics, Vancouver, BC, Canada).

[Ultrasound diagnosis of regional lymph node metastasis of the neck in patients with head-neck neoplasms: sono-morphologic criteria and diagnostic accuracy].

High resolution sonography is generally considered a diagnostic tool with high sensitivity but low specificity in the assessment of cervical lymph node metastases. This study shows, that excellent sonographic results regarding sensitivity and specificity can be achieved, if sonomorphologic parameters, such as size, shape, delineation and type of echo pattern are included in the evaluation. We compared sonomorphology and histology of 82 patients operated for head and neck malignancies.