Publications by authors named "G O Sawakuchi"
Aggressive breast cancers often fail or acquire resistance to radiotherapy. To develop new strategies to improve the outcome of aggressive breast cancer patients, we studied how PARP inhibition radiosensitizes breast cancer models to proton therapy, which is a radiotherapy modality that generates more DNA damage in the tumor than standard radiotherapy using photons. Two human BRCA1-mutated breast cancer cell lines and their isogenic BRCA1-recovered pairs were treated with a PARP inhibitor and irradiated with photons or protons.
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- SBRT for abdominal tumors faces challenges like respiratory motion and low tumor contrast, making accurate treatment difficult.
- Breath-hold treatments using CT-on-rails (CTOR) improve visualization of both tumors and surrounding tissues, helping to better align radiation targets and protect normal tissues.
- Case studies show that using diagnostic-quality CT guidance allows for precise adjustments in treatment alignment, effectively reducing radiation doses to sensitive organs like the stomach.
To develop an empirical model to predict carbon ion (C-ion) relative biological effectiveness (RBE).We used published cell survival data comprising 360 cell line/energy combinations to characterize the linear energy transfer (LET) dependence of cell radiosensitivity parameters describing the dose required to achieve a given survival level, e.g.
View Article and Find Full Text PDFAtaxia telangiectasia and Rad3-related protein (ATR) is a key DNA damage response protein that facilitates DNA damage repair and regulates cell cycle progression. As such, ATR is an important component of the cellular response to radiation, particularly in cancer cells, which show altered DNA damage response and aberrant cell cycle checkpoints. Therefore, ATR's pharmacological inhibition could be an effective radiosensitization strategy to improve radiotherapy.
View Article and Find Full Text PDFPurpose: Radiation therapy is an underinvestigated tool for priming the immune system in intact human breast cancers. We sought here to investigate if a preoperative radiation therapy boost delivered was associated with a significant change in tumor-infiltrating lymphocytes (TILs) in the tumor in estrogen receptor positive, HER2Neu nonamplified breast cancers.
Methods And Materials: A total of 20 patients were enrolled in a phase 2 clinical trial and received either 7.