Maternal Low-Protein Diet During Nursing Leads to Glucose-Insulin Dyshomeostasis and Pancreatic-Islet Dysfunction by Disrupting Glucocorticoid Responsiveness in Male Rats.

Both perinatal malnutrition and elevated glucocorticoids are pivotal triggers of the growing global pandemic of metabolic diseases. Here, we studied the effects of metabolic stress responsiveness on glucose-insulin homeostasis and pancreatic-islet function in male Wistar offspring whose mothers underwent protein restriction during lactation. During the first two weeks after delivery, lactating dams were fed a low-protein (4% protein, LP group) or normal-protein diet (22.

Effect of digital health applications with or without gamification on physical activity and cardiometabolic risk factors: a systematic review and meta-analysis of randomized controlled trials.

Background: Use of health applications (apps) to support healthy lifestyles has intensified. Different app features may support effectiveness, including gamification defined as the use of game elements in a non-game situation. Whether health apps with gamification can impact behaviour change and cardiometabolic risk factors remains unknown.

Towards a More Reliable Identification of Non-Conformities in Railway Cars: Experiments with Mask R-CNN, U-NET, and Ensembles on Unbalanced and Balanced Datasets.

In every business, equipment requires repair services. Over time, equipment wears out; however, with well-conducted and guided maintenance, this degradation can be controlled, and failed equipment can be restored to operational status. Preventive maintenance allows this concept to be applied, given the great advantages for large companies in reusing equipment and machinery, always putting the worker's health and safety first.

First report of aberrant sperm in Edessinae and analysis of the male reproductive system of Edessa rufomarginata (De Geer, 1773) (Hemiptera: Pentatomidae).

Edessinae is one of the ten subfamilies of Pentatomidae, and it is further divided into seven genera. Among these, Edessa Fabricius, 1803 is the most diverse genus, boasting around 300 species recognized for their ecological and economic significance worldwide. The inclusion of various pentatomids in the Edessa genus has led to mistakes in its taxonomy due to common morphological features and misidentifications.

Gold nanoparticles as innovative therapeutics for oral mucositis: A review of current evidence.

Oral mucositis (OM) remains a debilitating side effect in patients undergoing cancer therapy. DNA damage and oxidative stress generated by radiation and/or chemotherapy activate key inflammatory pathways, ultimately resulting in the destruction of the epithelial barrier, leading to microbial colonization, and ulceration. These ulcerative lesions are often extremely painful, compromising nutrition and oral hygiene, requiring intravenous nutritional support, resulting in longer periods of hospitalization and increased cost.