The study of changes in cardiovascular system and its regulation mechanisms occurring in 150 hypertension stage II patients on fasting diet has established the following phenomena: inhibition of the basic metabolism and generation of energy leading to low activity of central mechanisms regulating hemodynamics and reduced adaptability of such mechanisms, weakening of sympathetic influences on the myocardium and smooth muscle cells of the resistant vessels, their reduced contractility as a result of decreased calcium concentration and energy production in the cells.
View Article and Find Full Text PDFAn investigation into the pathogenesis of acute pneumonia in 37 young men made it possible to ascertain the role of arachidonic acid metabolites and hormonal regulation in the pathogenesis of the inflammatory reaction in acute bacterial pneumonia. At the initial stage of inflammation, invasion of the infectious agent leads to phagocytosis activation, stimulates the output of immunoglobulins belonging to different classes, which, binding antigens, form immune complexes influencing the output of biologically active substances. This is accompanied by the destruction of pulmonary tissue, release of lipid peroxidation radicals and proteinases, by the enhancement of arachidonic acid degradation under the destructive action on the membranes of phospholipase A2 cells to form prostaglandins participating in the changes in the tone of bronchi, pulmonary vessels and affecting blood coagulation.
View Article and Find Full Text PDFAn organized community numbering 900 normal subjects aged 18 to 19 years were examined. Acute pneumonia was encountered in 15% of persons of the group under study per year. To identify persons with premorbid condition of nonspecific pulmonary diseases, anamnestic screening and outpatient examinations (microbiological and immunologic studies) were performed.
View Article and Find Full Text PDFA general scheme of E. coli respiratory chain under aerobic oxidation with NAD.H2 is considered.
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