Publications by authors named "G Noce"
Patients with mild cognitive impairment due to Alzheimer's disease (ADMCI) typically show abnormally high delta (<4 Hz) and low alpha (8-12 Hz) rhythms measured from resting-state eyes-closed electroencephalographic (rsEEG) activity. Here, we hypothesized that the abnormalities in rsEEG activity may be greater in ADMCI patients than in those with MCI not due to AD (noADMCI). Furthermore, they may be associated with the diagnostic cerebrospinal fluid (CSF) amyloid-tau biomarkers in ADMCI patients.
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- The study investigated the impact of switching to a less neurotoxic antiretroviral therapy (ARV) on neurocognitive performance in people living with HIV who have cognitive impairments.
- Participants were randomly assigned to either continue their current treatment or switch to a less harmful ARV regimen (MARAND-X) for 24 weeks, with results measured using various cognitive tests and electroencephalography.
- While the overall neurocognitive scores improved modestly, significant improvements were only seen in specific memory functions for those in the MARAND-X group with better CNS penetration, indicating that the effectiveness of ARVs in the central nervous system may influence cognitive health.
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- Researchers investigated how "brain fog" in post-COVID patients, characterized by cognitive issues and fatigue, relates to abnormal brain activity measured by resting-state EEG (rsEEG).
- The study included post-COVID participants one year after their infection, many of whom reported fatigue symptoms but did not show cognitive or psychiatric disorders, contrasting them with matched controls who had not experienced COVID.
- Findings revealed that over 90% of post-COVID participants had no cognitive issues, yet exhibited lower rsEEG alpha activity, particularly among those with more severe fatigue, suggesting a link between abnormal brain rhythms, fatigue, and overall vigilance dysfunction in these individuals.
Pandemics have the potential to change how people behave and feel. The COVID-19 pandemic is no exception; thus, it may serve as a "challenging context" for understanding how pandemics affect people's minds. In this study, we used high-density electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) to examine the neural correlates of fear of contagion during the most critical moments of COVID-19 in Italy (i.
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- Resting-state EEG alpha rhythms are typically strong in healthy adults but show abnormalities in individuals with subjective memory complaints (SMC) related to Alzheimer's disease amyloidosis.
- An exploratory study with 161 SMC participants assessed how these alpha rhythms relate to brain connectivity, specifically between the thalamus and visual cortex, while considering factors like amyloid burden and educational attainment (cognitive reserve).
- Findings indicated that SMC participants with low amyloid levels and higher education showed a positive link between EEG rhythms and brain connectivity, suggesting that cognitive reserve may mitigate the early effects of Alzheimer's on brain function.