Design and Synthesis of Red-Absorbing Fluoran Leuco Dyes Supported by Computational Screening.

We report here on the design and synthesis of red-absorbing fluoran leuco dyes (LD). An essential part of the present dye development process is a computational screening of the candidate molecules, which allows for both time-efficient and accurate in silico characterization of the dyes. We focus our study here on the robust benzo[a]fluoran scaffold frequently used in leuco dyes.

Relationship Between Endothelial Function, Vital Parameters, and Cognitive Performance in Community Dwellers with Subjective Cognitive Decline: An Observational Study with Six Months Follow Up.

Background: With advancing age, cognitive decline is frequently associated with endothelial dysfunction, but data on vascular performance prior to the onset of mild cognitive impairment (MCI) is scarce.

Objective: To investigate the relationship between endothelial function, vital parameters and cognitive performance in older adults with subjective cognitive decline (SCD).

Methods: Forty-five volunteers aged 65 years and older with SCD underwent comprehensive geriatric assessment-based prognosis evaluation by means of the Multidimensional Prognostic Index (MPI), full neuropsychological examination and peripheral arterial tonometry measurement by means of EndoPAT™2000 to evaluate endothelial flexibility and vital parameters.

Long-Term Effects of the Multicomponent Program BrainProtect on Cognitive Function: One-Year Follow-Up in Healthy Adults.

Background: Age-related neuronal changes impact cognitive integrity, which is a major contributor to health and quality of life. The best strategy to prevent cognitive decline and Alzheimer's disease is still debated.

Objective: To investigate the long-term effects of the eight-week multicomponent training program BrainProtect on cognitive abilities compared to general health counseling (GHC) in cognitively healthy adults in Germany.

Electrostatic Surface Charging by Water Dewetting.

Water dewetting generates static electricity. We reviewed historical experiments of this phenomenon, and we studied the charging of polymer slides and metal electrode supported polymer films withdrawn vertically from a pool of aqueous solutions. For pure water, charging was negative and surface charge densities increased with the speed of dewetting, which we explain by the thermally activated entrainment of nanometer-sized water droplets or clusters charged by unbalanced adsorbed electric double-layer ions.