Publications by authors named "G Negrini"
Article Synopsis
- Immune-related liver injury (irLI) occurs more frequently in patients with hepatocellular carcinoma (HCC) treated with immune checkpoint inhibitors (ICIs) compared to those with other solid tumors, showing an incidence of 11.4% versus 2.6%.
- Patients with HCC experienced irLI earlier (median of 1.4 months) than those with other cancers (median of 4.7 months), but had higher rates of irLI resolution (72.1% vs. 58.3%).
- The study suggests that while irLI leads to improved overall survival in HCC patients with milder cases, it also results in lower need for corticosteroids, indicating a different response pattern compared to
Impact of influenza vaccination on survival of patients with advanced cancer receiving immune checkpoint inhibitors (INVIDIa-2): final results of the multicentre, prospective, observational study.
EClinicalMedicine
July 2023
Background: The prospective multicentre observational INVIDIa-2 study investigated the clinical effectiveness of influenza vaccination in patients with advanced cancer receiving immune checkpoint inhibitors (ICI). In this secondary analysis of the original trial, we aimed to assess the outcomes of patients to immunotherapy based on vaccine administration.
Methods: The original study enrolled patients with advanced solid tumours receiving ICI at 82 Italian Oncology Units from Oct 1, 2019, to Jan 31, 2020.
Objectives: To test reproducibility and predictive value of a simplified score for assessment of extraprostatic tumor extension (sEPE grade).
Methods: Sixty-five patients (mean age ± SD, 67 years ± 6.3) treated with radical prostatectomy for prostate cancer who underwent 1.
Background: An increased risk of nonalcoholic fatty liver disease (NAFLD) in patients with celiac disease (CD) adhering to a gluten-free diet (GFD) was recently reported. The nutritional composition of packaged gluten-free foods (PGFF) has been proposed as a possible cause. This hypothesis has not been investigated further, since a systematic structural nutritional interview for all patients would be problematic in clinical practice.
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- - Wheat and other gluten-containing grains are a major source of calories globally, leading to increased prevalence of celiac disease (CD), which was previously considered rare outside Europe; recent advancements have raised awareness and prompted better diagnosis strategies.
- - The study aimed to analyze the latest scientific guidelines on CD by reviewing papers published from January 2010 to January 2021, identifying notable differences among guidelines from seven reputable scientific societies.
- - Findings showed high concordance among guidelines but highlighted key differences in no-biopsy diagnosis options, HLA testing, and follow-up procedures, with significant changes, especially for children's diagnoses, anticipated in the near future.