In Silico Design and Investigation of Novel Thiazetidine Derivatives as Potent Inhibitors of PrpR in Mycobacterium tuberculosis.

Tuberculosis is one of the most life-threatening acute infectious diseases diagnosed in humans. In the present investigation, a series of 16 new disubstituted 1,3-thiazetidines derivatives is designed, and investigated via various in silico methods for their potential as anti-tubercular agent by evaluating their ability to block the active site of PrpR transcription factor protein of Mycobacterium tuberculosis. The efficacy of the molecules was initially assessed with the help of AutoDock Vina algorithm.

SnO Quantum Dots Distributed along VO Nanobelts for Utilization as a High-Capacity Storage Hybrid Material in Li-Ion Batteries.

In this study, the facile synthesis of SnO quantum dot (QD)-garnished VO nanobelts exhibiting significantly enhanced reversible capacity and outstanding cyclic stability for Li storage was achieved. Electrochemical impedance analysis revealed strong charge transfer kinetics related to that of VO nanobelts. The SnO QD-garnished VO nanobelts exhibited the highest discharge capacity of ca.

Diffusion characteristics of human annulus fibrosus-a study documenting the dependence of annulus fibrosus on end plate for diffusion.

Background: Intervertebral disc being avascular depends on nutrition from either the end plate or the annulus fibrosus (AF). The role of the end plate on disc diffusion had been extensively studied. However, diffusion of human AF remains poorly understood because of the lack of reliable techniques to study AF in vivo and non-invasively.

Optical analysis of RE(3+) (RE = Pr(3) (+) , Er(3) (+) and Nd(3) (+) ):cadmium lead boro tellurite glasses.

This article reports on the optical characterization of Pr(3) (+) -, Er(3) (+) - and Nd(3) (+) -doped cadmium lead boro tellurite (CLBT) glasses prepared using the melt quenching method. The visible-near infrared (Vis-NIR) absorption spectra of these glasses were analyzed systematically. On measuring the NIR emission spectra of Er(3) (+) :CLBT glasses, a broad emission band centered at 1536 nm ((4) I13 /2  → (4) I15 /2 ) was observed, as were three NIR emission bands at 900 nm ((4) F3 /2  → (4) I9 /2 ), 1069 nm ((4) F3 /2  → (4) I11 /2 ) and 1338 nm ((4) F3 /2  → (4) I13 /2 ) from Nd(3) (+) :CLBT glasses and an NIR emission band at 1334 nm ((1) G4  → (3) H5 ) from Pr(3) (+) :CLBT glasses at an excitation wavelength (λex ) of 514.

Increasing the specimen adequacy of transpedicular vertebral body biopsies. Role of intraoperative scrape cytology.

Background Context: Obtaining adequate representative material has been a problem in transpedicular vertebral body biopsies resulting in inconclusive diagnosis and delayed management. By rapidly confirming the adequacy of the material intraoperatively, the rate of negative biopsies can be minimized. Present study evaluates the role of intraoperative cytology in increasing the diagnostic yield of vertebral biopsies.