Publications by authors named "G Nagar"
Article Synopsis
- * Activin A Receptor Type 1 (ACVR1) is crucial for bone morphogenetic protein signaling and is linked to rare conditions like fibrodysplasia ossificans progressiva and diffuse intrinsic pontine glioma due to specific genetic mutations.
- * Bioinformatics analyses identified seven destabilizing mutations in ACVR1 that may affect protein function and are associated with various cancers, suggesting they could be important for future studies in precision medicine for rare diseases.
Article Synopsis
- * Findings showed severe deformities in the ovaries, including damaged oocytes and significant vacuolation, which likely hinder reproductive functions and overall survival of the ticks.
- * The results indicate that both drugs affect not just the nervous system but also other critical organs, suggesting potential routes for improving tick control strategies.
Article Synopsis
- - The text discusses the significant threat that genetic diversity in ticks poses to livestock health and agricultural economies globally, highlighting their adaptability to various environments and hosts.
- - It reviews three key genetic markers—COX1 gene, ribosomal genes, and microsatellites—used to study tick genetic diversity, emphasizing the strengths and limitations of each marker in species differentiation and population studies.
- - The implications of genetic diversity for vaccine development, particularly the Bm86 vaccine, and the understanding of synthetic pyrethroid resistance in ticks are also addressed, underscoring the need for tailored genetic approaches in tick management strategies.
Aims And Background: Sepsis is a dysregulated host response to an infection that causes organ failure that poses a serious risk to life. Although culture results are not always available right away and the majority of patients continue to test culture negative, microbial culture is still the gold standard for diagnosing sepsis. Therefore, the objective of the current study was to assess absolute eosinophil count as a new marker for diagnosing sepsis and also to assess the prognosis of the patient in relation to Sequential Organ Failure Assessment (SOFA)/quick Sequential Organ Failure Assessment (qSOFA) score.
View Article and Find Full Text PDFIn osteoarthritis (OA), the degradation of cartilage is primarily driven by matrix metalloprotease-13 (MMP-13). Hence, the inhibition of MMP-13 has emerged as an attractive target for OA treatment. Among the various approaches that are being explored for MMP-13 regulation, blocking of the enzyme with specific binding molecules appears to be a more promising strategy for preventing cartilage degeneration.
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