Publications by authors named "G NAKAMURA"
The μ-opioid receptor (MOR) is a G-protein-coupled receptor (GPCR) that mediates both analgesic effects and adverse effects of opioid drugs. Despite extensive efforts to develop a signal-biased drug, drugs with sufficiently reduced side effects have not been established, in part owing to lack of comprehensive signal transducer profiles of MOR. In this study, by profiling the activity of signal transducers including G proteins and GPCR kinases (GRKs), we revealed an unprecedented mechanism of selective GRK3 activation by Gβ, leading to β-arrestin recruitment.
View Article and Find Full Text PDFIt is widely perceived how research institutes have been adopting the discourse of champions of diversity, inclusion, and equity (DEI) in recent years. Despite progress in diversity and inclusion in the academic environment, we highlight here that nothing or, at very best, little work has been done to overcome the scientific labor division in academic research that promotes neocolonial practices in academic recognition and jeopardizes equity. In this piece, we bring secondary data that reinforce biased patterns in academic recognition between Global North and South (geographical markers and citation bias), and propose three actions that should be adopted by researchers, research institutes, journals, and scientific societies from the Global North that allows for a fairer recognition of the academic expertise produced by the Global South.
View Article and Find Full Text PDFObjectives: Interleukin (IL)-2 production by mouse spleen cells stimulated with an anti-CD3 antibody is significantly enhanced by caffeic acid phenethyl ester (CAPE), a major constituent of Chinese propolis (CP). In this study, we evaluated the functional significance of IL-2 in CAPE-treated activated spleen cells.
Methods: Mouse spleen cells were stimulated with an anti-CD3 monoclonal antibody in the presence of CAPE.