Publications by authors named "G N Manjunath"
Introduction Head and neck cancers account for 30% of malignancies in India and oral squamous cell carcinoma is most common. 80% of the patients present with locally advanced disease and many of them are inoperable. In this study we documented the outcomes of neoadjuvant chemotherapy (NACT) in locally advanced oral cancer staged T4 with regards to downstaging the disease and to make the tumor more amenable for surgery with better access.
View Article and Find Full Text PDFBreast cancer genomic analyses reveal genes, mutations, and signaling networks.
Funct Integr Genomics
November 2024
Breast cancer (BC) is the most commonly diagnosed cancer and the predominant cause of death in women. BC is a complex disorder, and the exploration of several types of BC omic data, highlighting genes, perturbations, signaling and cellular mechanisms, is needed. We collected mutational data from 9,555 BC samples using cBioPortal.
View Article and Find Full Text PDFArticle Synopsis
- Pediatric cancer (PAEC) is linked to gene mutations and disrupted cell signaling pathways, necessitating further research to grasp tumor progression mechanisms.
- Analysis of 6568 PAEC samples identified 827 genes, categorized into four tiers based on mutation frequency, with key genes like TP53, NRAS, and KRAS being crucial in various signaling pathways.
- The study underscores the importance of these genes for therapeutic and diagnostic purposes and points to the need for continued exploration of metabolic pathways and their role in PAEC risk.
Article Synopsis
- Testicular cancers, like embryonal cell carcinoma, rarely spread to the heart, but when they do, it usually indicates widespread disease.
- A 28-year-old man experienced cardiac metastasis from his testicular cancer, but his symptoms improved following chemotherapy.
- It's crucial for healthcare providers to maintain a high suspicion for heart issues in patients with chest symptoms and to involve cardiologists early for better treatment outcomes.
Article Synopsis
- A clinical isolate of strain JH-1 carries genes for cytolethal distending toxin (CDT) on a conjugative plasmid, but a mutant without CDT still shows invasiveness and diarrhea-causing ability.
- Whole genome sequencing revealed two distinct type III secretion systems (T3SS) in strain JH-1, with one located on the chromosome and the other on a mega-plasmid, indicating a unique genetic structure that contributes to its virulence.
- The plasmid's T3SS is functional and can transfer between strains, suggesting a mechanism for sharing virulence traits among pathogenic bacteria, enhancing our understanding of their disease-causing abilities.