Publications by authors named "G N Malavige"
Background Elderly individuals, those with comorbidities and pregnant women are at a higher risk of developing severe dengue and succumbing to their illness. However, an increased incidence of severe dengue and fatalities are seen in females of the reproductive age. As per vaginal (PV) bleeding is an important complication that has not been well characterized, we sought to determine the frequency, complications and disease outcomes in women who develop PV bleeding.
View Article and Find Full Text PDFTo face the current and emerging challenges due to infectious diseases, global research communities must comprehend the challenges faced by scientists in low-income and lower-middle-income countries. Here we address pertinent issues regarding funding and collaboration inequalities that could potentially cripple economic and healthcare systems, escalating to bigger global threats.
View Article and Find Full Text PDFArticle Synopsis
- Influenza A is a priority pathogen for the WHO due to its pandemic potential, leading to a study on its molecular epidemiology in the Western Province of Sri Lanka to inform vaccine selection and understand strain evolution.
- The study involved 349 participants with respiratory symptoms, detecting Influenza A in 14%, B in 5.7%, and SARS-CoV-2 in 11.7% of cases, with some individuals having co-infections.
- Genomic analysis revealed specific clades and subclades of H1N1 and H3N2 strains, along with several significant amino acid substitutions in the viral proteins, indicating ongoing viral evolution.
Background: As many studies have shown conflicting results regarding the extent of viraemia and clinical disease severity, we sought to investigate if viraemia during early dengue illness is associated with subsequent clinical disease severity.
Methods: Realtime PCR was carried out to identify the dengue virus (DENV serotype), in 362 patients, presenting within the first 4 days of illness, from 2017 to 2022, in Colombo Sri Lanka. To characterize subsequent clinical disease severity, all patients were followed throughout their illness daily and disease severity classified according to WHO 1997 and 2009 disease classification.
Article Synopsis
- Influenza A is a significant concern for pandemics, prompting a study of its evolution in Sri Lanka to aid in vaccine selection.
- A total of 349 patients with respiratory symptoms were analyzed, revealing that 14% had Influenza A, alongside lower rates of Influenza B and SARS-CoV-2, with several co-infections noted.
- Findings included specific genetic clade classifications for H1N1 and H3N2 strains, along with multiple amino acid changes over time, highlighting the need for continuous monitoring of influenza viruses in the region.