Erythropoietin Mimetic Peptide (pHBSP) Corrects Endothelial Dysfunction in a Rat Model of Preeclampsia.

Preeclampsia is a severe disease of late pregnancy. Etiological factors and a pathogenetic pattern of events still require significant clarification, but it is now recognized that a large role is played by placentation disorders and emerging endothelial dysfunction. The administration of short-chain peptides mimicking the spatial structure of the B erythropoietin chain may become one of the directions of searching for new drugs for preeclampsia prevention and therapy.

Studies to Elucidate the Effects of Furostanol Glycosides from Cell Culture in a Rat Model of Endothelial Dysfunction.

Currently, there is no doubt surrounding a theory that the cardiotropic effects of sex hormones can be due to their direct effect on the cardiovascular system. In recent years, interest in the study of steroid glycosides has increased. We studied the effects of furostanol glycosides (protodioscin and deltozid) from the cell culture of the (laboratory code DM-05) on the physiological and biochemical parameters of vascular endothelial function in hypoestrogen-induced endothelial dysfunction after bilateral ovariectomy.

Thermodynamic approach to the description of dislocation mobility in quasicrystals.

Dislocation mobility in quasicrystals is calculated using basic thermodynamic and hydrodynamic equations. The dependence of the dislocation mobility on viscosity, vacancies and phasons is given. It is shown that the phasonic defects make the major contribution to the inverse mobility of the free segments of dislocations.

[The protective action of essentiale, riboxin, and elkar against hemotoxic anemia].

The introduction of phenylhydrazine in rats inhibited the hemopoiesis, decreased the functional activity of immune cells, hepatocytes and myocytes, and reduced the work capacity. The combined administration of essentiale and riboxin decreased the expression of inhibition of the nonspecific resistance and immune reactivity in rats pretreated with phenylhydrazine. The combined use of essentiale and elkar produced a hepatoprotective effect in rats with phenylhydrazine-induced hemotoxic anemia.

[Protective effects of the regulators of energy metabolism and essentiale in case of nitrite intoxication].

The objective of this investigation was to assess immuno-, hepato- and actoprotective activity of mildronate and the impact of riboxin, elcar and essentiale on this drug in Wistar rats receiving the injections of sodium nitrite. The parameters characterizing non-specific resistance, immunological reactivity, the membranes state, detoxicating hepatic activity and physical performance. Mildronate administration increased functional activity of immune cells, hepatocytes and myocytes (but not up to normal limit) that had been reduced by sodium nitrite.