Engraft: A Collaborative Learning Health Network for Enhanced Transplant and Cellular Therapy Outcomes.

The Engraft Learning Health Network (LHN) aims to improve outcomes for patients undergoing transplant and cellular therapy (TCT) through a collaborative, data-driven approach. Engraft brings together diverse stakeholders, including clinicians, patients, caregivers, and institutions, to standardize best practices and accelerate the dissemination of innovations in TCT care. By establishing a multicenter, real-world clinical registry focused on rapid-cycle quality improvement (QI) and implementation research, Engraft seeks to reduce variability in clinical practice to improve TCT outcomes across centers.

Iodide Double Perovskites and the Limits of their Structural Stability.

While halide double perovskites AM(I)M(III)X have attracted significant attention, examples involving iodides are rare. We examine the limits of the structural stability of iodide double perovskites, presenting the synthesis and single-crystal structures of CsNaScI and CsNaYI. Bypassing the common expectation that iodides have small band gaps, these compounds display optical gaps of 3.

Scalable Synthesis of Degradable Copolymers Containing α-Lipoic Acid via Miniemulsion Polymerization.

A robust method is described to synthesize degradable copolymers under aqueous miniemulsion conditions using α-lipoic acid as a cheap and scalable building block. Simple formulations of α-lipoic acid (up to 10 mol %), -butyl acrylate, a surfactant, and a costabilizer generate stable micelles in water with particle sizes <200 nm. The ready availability of these starting materials facilitated performing polymerization reactions at large scales (4 L), yielding 600 g of poly(-butyl acrylate--α-lipoic acid) latexes that degrade under reducing conditions (250 kg mol → 20 kg mol).

Embryonic macrophages support endocrine commitment during human pancreatic differentiation.

Organogenesis is a complex process that relies on a dynamic interplay between extrinsic factors originating from the microenvironment and tissue-specific intrinsic factors. For pancreatic endocrine cells, the local niche consists of acinar and ductal cells as well as neuronal, immune, endothelial, and stromal cells. Hematopoietic cells have been detected in human pancreas as early as 6 post-conception weeks, but whether they play a role during human endocrinogenesis remains unknown.

Tuning the Optical Absorption Edge of Vacancy-Ordered Double Perovskites through Metal Precursor and Solvent Selection.

Vacancy-ordered double perovskites with the formula (where is a +1 cation, is a +4 metal, and is a halide ion) offer improved ambient stability over other main-group halide perovskites and potentially reduced toxicity compared to those containing lead. These compounds are readily formed through a number of synthetic routes; however, the manner in which the synthetic route affects the resulting structure or optoelectronic properties has not been examined. Here, we investigate the role of distinct precursors and solvents in the formation of the indirect band gap vacancy-ordered double perovskite CsTeBr.