ProEnd: A Comprehensive Database for Identifying HbYX Motif-Containing Proteins Across the Tree of Life.

The proteasome plays a crucial role in cellular homeostasis by degrading misfolded, damaged, or unnecessary proteins. Understanding the regulatory mechanisms of proteasome activity is vital, particularly the interaction with activators containing the hydrophobic-tyrosine-any amino acid (HbYX) motif. Here, we present ProEnd, a comprehensive database designed to identify and catalog HbYX motif-containing proteins across the tree of life.

Proteasome hyperactivation rewires the proteome enhancing stress resistance, proteostasis, lipid metabolism and ERAD in .

Proteasome dysfunction is implicated in the pathogenesis of neurodegenerative diseases and age-related proteinopathies. Using a model, we demonstrate that 20S proteasome hyperactivation, facilitated by 20S gate-opening, accelerates the targeting of intrinsically disordered proteins. This leads to increased protein synthesis, extensive rewiring of the proteome and transcriptome, enhanced oxidative stress defense, accelerated lipid metabolism, and peroxisome proliferation.

Fully 3D Printed Tin Selenide (SnSe) Thermoelectric Generators with Alternating -Type and Type Legs.

Tin selenide (SnSe) has attracted much attention in the field of thermoelectrics since the discovery of the record figure of merit () of 2.6 ± 0.3.

An annotated water-filled, and dry potholes dataset for deep learning applications.

Potholes have long posed a challenging risk to automated systems due to their random and stochastic shapes and the reflectiveness of their surface when filled with water, whether it is "muddy" water or clear water. This has formed a significant limitation to autonomous assistive technologies such as Electric-Powered Wheelchairs (EPWs), mobility scooters, etc. due to the risk potholes pose on the user's well-being as it could cause severe falls and injuries as well as neck and back problems.