[The effect of ketalar on fatty acid metabolism in the myocardium].

The intraperitoneal administration of ketalar in a dose of 50 mg/kg elevated the myocardial levels of triglycerides, reduced non-esterified fatty acids and enhanced uncontrolled mitochondrial respiration during oxidation of caprylate and palmitoylcarnitine. The efficiency of phosphorylation remained unchanged.

[Energy substrate metabolism in myocardium in the dynamics of hypothermic perfusion in combined cardioplegia in an experiment].

Experiments on 16 mongrel dogs have indicated that an anesthetic aid during cardiosurgical operations, which involves current multicomponent anesthesia, hypothermal perfusion and cardioplegia, fails to provide a complete protection of the myocardium from ischemia and a balanced uptake of energy substrates in the immediate postperfusion period.

[Endogenous humoral regulators directly before an operation].

It has been shown that modern premedication techniques do not prevent the activation of the sympathoadrenal system and the enhanced synthesis of cyclic nucleotides and prostaglandin-like compounds in response to preoperative stress. In a great number of patients there are no hemodynamic shifts in the nearest preoperative period, as an increased production of prostaglandins E and cyclic nucleotides (cAMP), that is of compensatory value, is observed. When normal relations between endogenous vasoactive substances with constricting and dilating effects are damaged, a hyperdynamic reaction ensures.

[The role of humoral factors in the pathogenesis of the postoperative syndrome].

Blood plasma levels of "pain substances" (serotonin, histamine, prostaglandin F2 alpha, adrenaline /A/) and neuropeptides (beta-endorphin, somatostatin) have been evaluated in 39 patients during the early postoperative period after lung and mediastinum surgery. The studies have shown that the content of these biologically active substances increases considerably. Following stellate ganglion blockade A concentration decreased significantly, the uptake of narcotic analgesics used for postoperative analgesia reduced 1.