Vaccination in the context of the COVID-19 pandemic.

In this review, we described the history of vaccination, the different types of vaccines, and how vaccination coverage has been affected by the current COVID-19 pandemic. The effectiveness of the vaccines under metabolic host conditions is analyzed, especially when people have lost their immunocompetence, such as in patients with chronic kidney disease who are in dialysis treatment. Vaccines are produced in a variety of industrial methods, modifying costs.

Growth hormone ameliorates high glucose-induced steatosis on in vitro cultured human HepG2 hepatocytes by inhibiting de novo lipogenesis via ChREBP and FAS suppression.

Objective: Growth hormone (GH) deficiency has been associated with increased steatosis but the molecular mechanism has not been fully elucidated. We investigated the effect of GH on lipid accumulation of HepG2 cells cultured on an in vitro steatosis model and examined the potential involvement of insulin-like growth factor 1 (IGF-1) as well as lipogenic and lipolytic molecules.

Methods: Control and steatosis conditions were induced by culturing HepG2 cells with 5.

Gender-specific differences in clinical and metabolic variables associated with NAFLD in a Mexican pediatric population.

Introduction And Objectives: Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease in children and it is more prevalent in Hispanic males. The gender differences can be explained by body fat distribution, lifestyle, or sex hormone metabolism. We evaluated anthropometric and metabolic differences by gender in children with and without NAFLD.

Inter- and intra-ethnic group comparison of metabolic syndrome components among morbidly obese adolescents.

This study explored inter- (between) and intra- (within) ethnic group differences in metabolic syndrome components among a clinical sample of morbidly obese (body mass index [BMI] > or =97th percentile for age and sex) 12- to 18-year-olds originating from Latin America and the Caribbean Basin and a matched (age/ethnicity/sex/BMI percentile) national sample (N=208, both samples) of Mexican American and non-Hispanic blacks from the 1999 to 2006 National Health and Nutrition Examination Survey (NHANES). Mexican American and non-Hispanic black boys from the NHANES/national sample had significantly higher mean fasting glucose levels compared with Latin and Caribbean blacks (98.50 vs 85.

Three-yr follow-up of a type 1 diabetes mellitus patient with an islet xenotransplant.

In order to alleviate the shortage of human donors, the use of porcine islets of Langerhans for xenotransplantation in diabetic patients has been proposed as a solution. To overcome rejection, we have developed a procedure for protecting the islets by combining them with Sertoli cells and placing them in a novel subcutaneous device, that generates an autologous collagen covering. A type 1 diabetic woman was closely monitored for 10 months, and then transplanted in two devices with two months of difference and a third time after 22 months.