Publications by authors named "G N Chelomina"
Article Synopsis
- * This study is the first to analyze the genome-wide molecular variation of C. sinensis across six populations, revealing significant genetic differences, particularly between northern and southern regions, indicating potentially varied behavior and treatment responses.
- * High genetic diversity suggests C. sinensis can adapt to different environments or hosts, and identifying stable genes might help in developing new treatments, while the genomic methods used can also be applied to other neglected tropical disease-causing parasites.
Parasites cause numerous health issues in humans, eventually leading to significant social and economic damage; however, the mechanisms of parasite-mediated pathogenesis are not well understood. Nevertheless, it is clearly evidenced that cancerogenic fluke-induced chronic inflammations and cancer are closely associated with oxidative stress. (1) Methods: The infection's genotoxic potential was assessed in a rat model of simultaneous pulmonary and hepatic paragonimiasis by the alkaline version of single-cell gel electrophoresis (comet assay).
View Article and Find Full Text PDFArticle Synopsis
- Long-term cultivation of cell lines affects the synthesis of biologically active substances in traditional medicine, with a focus on the rDNA cluster variations in Oriental ginseng.
- Analysis of cell lines cultivated for 6 and 24 years revealed mutations in 18S rDNA sequences, correlating with increased nucleoli and chromosome numbers.
- The study indicates that these changes are linked to somaclonal variation and may alter gene expression regulation through heterogeneous ribosomes, highlighting the importance of specific culture conditions on genetic stability.
Article Synopsis
- Clonorchiasis, caused by the Chinese liver fluke Clonorchis sinensis, is linked to bile duct cancer and has limited understanding regarding its genetics.
- Researchers conducted a genetic study on 183 C. sinensis samples from various regions of China and the Russian Far East, uncovering significant genetic variation.
- The findings indicate high dispersal rates of the parasite without clear ties to specific locations or host species, paving the way for further research on its biological and epidemiological implications related to human health.
The small subunit ribosomal RNA (SSU rRNA) is widely used phylogenetic marker in broad groups of organisms and its secondary structure increasingly attracts the attention of researchers as supplementary tool in sequence alignment and advanced phylogenetic studies. Its comparative analysis provides a great contribution to evolutionary biology, allowing find out how the SSU rRNA secondary structure originated, developed and evolved. Herein, we provide the first data on the putative SSU rRNA secondary structures of the Plagiorchiida species.
View Article and Find Full Text PDF