Polyol-Assisted Synthesis of Ni/Cu/Ag Trimetallic Nanoparticles for Nonlinear Optical Applications.

Trimetallic nanoparticles (TMNPs) have opened a broad spectrum of applications with a new class of materialistic combinations in several fields from electronics to medicinal and environmental applications. In this work, we report the synthesis and characterization of Ni/Cu/Ag TMNPs using the polyol method and their nonlinear optical (NLO) studies. A broad surface plasmon resonance (SPR) peak at 443 nm evidences the formation of the Ni/Cu/Ag TMNPs with a peak shift compared to their mono- or bimetallic counterparts.

Randomized Controlled Trial Comparing the Effects of Preoperative Carbohydrate and Non-carbohydrate Loading on Gastric Emptying in Diabetic and Non-diabetic Patients Posted for Elective Surgery.

Background Preoperative fasting for six hours and accepting clear fluids till two hours of surgery is followed as a regular practice. Carbohydrate-rich fluids antagonize catabolism and are claimed to be tolerated better. This study aims to compare the effect of carbohydrate-rich drinks on gastric volume and blood sugar control in diabetic and non-diabetic patients undergoing elective surgery with plain water.

Defensin-based therapeutic peptide design in attenuating V30M TTR-induced Familial Amyloid Polyneuropathy.

Unlabelled: In the present study, we aimed to formulate an effective therapeutic candidate against V30M mutant transthyretin (TTR) protein to hinder its pathogenic misfolding. Nicotiana alata Defensin 1 (NaD1) Antimicrobial Peptide (AMP) was availed due to its tendency to aggregate, which may compete for aggregation-prone regions of pathogenic TTR protein. Based on NaD1's potential to bind to V30M TTR, we proposed NaD1-derived tetra peptides: CKTE and SKIL to be initial therapeutic candidates.

Characterization and antimicrobial evaluation of anthraquinones and triterpenes from .

Chemical investigation of roots of the plant, Linn, led to the isolation of an undescribed anthraquinone, cordifoquinone R, determined as 1,2-dihydroxy-6-methoxyanthracene-9,10-dione ( based on the 1D and 2D NMR analyses and HRESIMS. Ten other known compounds 1,4-dihydroxy-2-methoxyanthracene-9,10-dione (), rubiadin (), xanthopurpurin (), 1-methoxy-3-hydroxy-2-carbomethoxy-9,10-anthraquinone (), alizarin (), β-sitosterol glucoside (), scopoletin (), oleanolic acid, (), pomolic acid (), queretaroic acid () were also isolated. Out of these compounds, , , and are first reported from this plant species.

Computer aided therapeutic tripeptide design, in alleviating the pathogenic proclivities of nocuous α-synuclein fibrils.

Parkinson's disorder (PD) exacerbates neuronal degeneration of motor nerves, thereby effectuating uncoordinated movements and tremors. Aberrant alpha-synuclein (α-syn) is culpable of triggering PD, wherein cytotoxic amyloid aggregates of α-syn get deposited in motor neurons to instigate neuro-degeneration. Amyloid aggregates, typically rich in beta sheets are cardinal targets to mitigate their neurotoxic effects.