Publications by authors named "G N Bowden"
Background And Objectives: Oligodendrogliomas are primary brain tumors classified as isocitrate deshydrogenase-mutant and 1p19q codeleted in the 2021 World Health Organization Classification of central nervous system tumors. Surgical resection, radiotherapy, and chemotherapy are well-established management options for these tumors. Few studies have evaluated the efficacy of stereotactic radiosurgery (SRS) for oligodendroglioma.
View Article and Find Full Text PDFObjective: This study aimed to evaluate local control (LC) of tumors, patient overall survival (OS), and the safety of stereotactic radiosurgery (SRS) for esophageal cancer brain metastases (EBMs).
Methods: This retrospective cohort study used data from 15 International Radiosurgery Research Foundation facilities encompassing 67 patients with 185 EBMs managed using SRS between January 2000 and May 2022. The median patient age was 63 years, with a male predominance (92.
Background And Objectives: Pineocytomas are grade 1 tumors arising from the pineal parenchyma. Gross total resection can potentially cure these benign lesions but can be associated with morbidity. This study was designed to provide multi-institutional data to evaluate the results of stereotactic radiosurgery (SRS) for pineocytomas.
View Article and Find Full Text PDFBrainstem cerebral cavernous malformations (CCM) are clinically more aggressive compared to superficial CCMs. Due to their location, resection can be challenging, making stereotactic radiosurgery (SRS) an attractive alternative for symptomatic patient. Brainstem CCM patients (n = 170) were treated with Gamma Knife SRS at 11 radiosurgical centers.
View Article and Find Full Text PDFArticle Synopsis
- - Purpose: The study aims to enhance understanding of diabetes by monitoring β-cell mass and function using a combined PET/MRI protocol, which allows for real-time assessment without needing to pre-label isolated cells.
- - Methods: Islets were transplanted into mice, and their mass and function were tracked using PET and MRI at various intervals post-transplant, with validations through additional imaging techniques to ensure accuracy.
- - Results: The imaging approach successfully monitored the growth and function of transplanted islets, showing a promising correlation between in vivo imaging data and validation methods, while highlighting the need for further research to optimize measurement of β-cell function.