Publications by authors named "G Morel"
Phytate in plants (inositol phosphates, InsPs) affects mineral bioavailability. However, methods for their quantification may lead to variable results, and some are nonspecific (spectrophotometric techniques). In this study, ion-pair high-performance liquid chromatography (HPLC) was coupled with post-column derivatization to allow fluorescence detection (FLD, λ324/λ364 nm) of InsPs.
View Article and Find Full Text PDFRetinoblastoma (RB) proteins are highly conserved transcriptional regulators that play important roles during development by regulating cell-cycle gene expression. RBL2 dysfunction has been linked to a severe neurodevelopmental disorder. However, to date, clinical features have only been described in six individuals carrying five biallelic predicted loss of function (pLOF) variants.
View Article and Find Full Text PDFPrevious studies have shown a correlation between chocolate sensory profile and certain (bio)chemical components. The aim of this study was to examine the sensorial profile and organic acid content of three lab scale chocolate brands produced from different cocoa genotypes. The sensorial evaluation was examined by a team of 12 panelists and evaluation of aroma volatiles was done by means of HS-SPME-GC-MS.
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- Fetal Alcohol Spectrum Disorders (FASDs) are often underdiagnosed or misdiagnosed, highlighting the need for quicker identification and better support for affected families.* -
- A study involving 147 children and adolescents with FASDs revealed that 42.9% had paternal alcohol consumption and 33.3% were born prematurely, with many exhibiting learning difficulties and motor skill disabilities.* -
- The study found that almost 23% of these patients also showed genetic anomalies, suggesting that FASDs entail a combination of prenatal alcohol exposure, prematurity, challenging social conditions, and genetic factors.*
Acylaminoindazole-based inhibitors of CDKL2 were identified via analyses of cell-free binding and selectivity data. Compound was selected as a CDKL2 chemical probe based on its potent inhibition of CDKL2 enzymatic activity, engagement of CDKL2 in cells, and excellent kinome-wide selectivity, especially when used in cells. Compound was designed as a negative control to be used alongside compound in experiments to interrogate CDKL2-mediated biology.
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