Breast gel based on Boswellia serrata, Betaine and myo-Inositol improves cyclic mastodynia in fertile women: A retrospective clinical study.

Background: The management of mastodynia plays a central role in improving women quality of life. Despite its high occurrence, specific therapeutic guidelines for mastalgia are still lacking. Available therapies include unspecific anti-inflammatories, even though they may often expose to undesirable effects and low compliance.

Distance- and Angle-Based Hybrid Localization Integrated in the IEEE 802.15.4 TSCH Communication Protocol.

Accurate localization of devices within Internet of Things (IoT) networks is driven by the emergence of novel applications that require context awareness to improve operational efficiency, resource management, automation, and safety in industry and smart cities. With the Integrated Localization and Communication (ILAC) functionality, IoT devices can simultaneously exchange data and determine their position in space, resulting in maximized resource utilization with reduced deployment and operational costs. Localization capability in challenging scenarios, including harsh environments with complex geometry and obstacles, can be provided with robust, reliable, and energy-efficient communication protocols able to combat impairments caused by interference and multipath, such as the IEEE 802.

Targeting oncogenic KRAS with molecular brush-conjugated antisense oligonucleotides.

The mutant form of the guanosine triphosphatase (GTPase) KRAS is a key driver in human tumors but remains a challenging therapeutic target, making cancers a highly unmet clinical need. Here, we report a class of bottlebrush polyethylene glycol (PEG)-conjugated antisense oligonucleotides (ASOs) for potent in vivo KRAS depletion. Owing to their highly branched architecture, these molecular nanoconstructs suppress nearly all side effects associated with DNA-protein interactions and substantially enhance the pharmacological properties of the ASO, such as plasma pharmacokinetics and tumor uptake.

Utility of procalcitonin and C-reactive protein as predictors of Gram-negative bacteremia in febrile hematological outpatients.

This study was designed to determine the utility of procalcitonin (PCT) and C-reactive protein (CRP) as predictors of Gram-negative bloodstream infection (GN-BSI) in hematological febrile outpatients at the time of the emergency unit admission. Overall, 286 febrile episodes, which included 42 GN-BSI (16%), were considered. PCT levels at patient admission were statistically higher in GNB-BSI when compared to Gram-positive bacteria BSI (median 4.