A Machine Learning-Based Model for Preoperative Assessment and Malignancy Prediction in Patients with Atypia of Undetermined Significance Thyroid Nodules.

The aim of this study was to investigate the preoperative clinical and hematologic variables, including the neutrophil-to-lymphocyte ratio (NLR), that can be used to predict malignancy in patients with atypia of undetermined significance (AUS) thyroid nodules; we further aimed to develop a machine learning-based prediction model. We enrolled 280 patients who underwent surgery for AUS nodules at the Wonju Severance Christian Hospital between 2018 and 2022. A logistic regression-based model was trained and tested using cross-validation, with the performance evaluated using metrics such as the area under the receiver operating characteristic curve (AUROC).

Strategic design of emerging (K,Na)NbO-based perovskites for high-performance piezocatalysis and photo-piezocatalysis.

As a leading Pb-free perovskite material (ABO-type), potassium sodium niobate (K,Na)NbO (KNN)-based ferroelectrics/piezoelectrics have been widely used in electronics, energy conversion, and storage due to their exceptional ability to interconvert mechanical and electrical energies. Beyond traditional applications, the piezoelectric potential generated by mechanical strain or stress modifies their energy band structures and facilitates charge carrier separation and transport, drawing increasing attention in emerging fields such as piezocatalysis and photo-piezocatalysis. With excellent piezoelectric properties, chemical/thermal stability, and strain-tuning capability, KNN-based materials show great promise for high-performance piezocatalytic applications.

Neddylation steers the fate of cellular receptors.

Cellular receptors regulate physiological responses by interacting with ligands, thus playing a crucial role in intercellular communication. Receptors are categorized on the basis of their location and engage in diverse biochemical mechanisms, which include posttranslational modifications (PTMs). Considering the broad impact and diversity of PTMs on cellular functions, we focus narrowly on neddylation, a modification closely resembling ubiquitination.

Racial disparities in early postoperative proximal humerus fracture outcomes: Do minorities face longer operative times, extended hospital stays, and higher risks?

Background: Racial disparities in orthopedic surgery outcomes have been extensively documented, highlighting systemic biases in care. Proximal humerus fractures (PHFs), about 6% of all fractures, are rising, especially among the elderly. Despite the prevalence of PHFs, a research gap exists regarding racial disparities in postoperative complications and outcomes.