Publications by authors named "G Montesi"
A paradigmatic case is presented of subarachnoid hemorrhage as the initial sign of bacterial endocarditis on a mechanical cardiac prosthesis, in the absence of symptoms and echocardiographic evidence of infective endocarditis and vegetation. The presentation emphasizes the need to pursue a diagnostic workup for bacterial endocarditis whenever a patient with a mechanical prosthesis presents to the emergency department with focal neurologic signs. In addition, it highlights the potential use of second-level diagnostic tools to assess the extent of abscess presence and lesion extension to other cardiac structures for proper surgical planning.
View Article and Find Full Text PDFArticle Synopsis
- A patient with prosthetic aortic valve endocarditis faced severe complications, necessitating urgent surgery due to significant valve detachment and prior cardiac surgeries.
- Preoperative imaging uncovered a rare left superior vena cava anomaly, which required special techniques for safe surgery.
- The surgical procedure involved removing the infected valve and tissue, then replacing it with a cryopreserved aortic homograft for better fit and function.
Article Synopsis
- A phase 2a clinical trial demonstrated that the leishmaniasis vaccine ChAd63-KH is safe and can generate an immune response in Sudanese patients with post kala-azar dermal leishmaniasis (PKDL).
- A follow-up phase 2b randomized trial assessed its therapeutic efficacy, comparing the vaccine to a placebo in 86 participants with uncomplicated PKDL.
- Results indicated no significant improvement in clinical outcomes or severity of PKDL, suggesting that ChAd63-KH does not provide therapeutic benefits for this condition in the studied population.
Background: The Study Group for the Biology and Treatment of the OligoMetastatic Disease on behalf of the Italian Association of Radiotherapy and Clinical Oncology (AIRO) has conducted a national survey with the aim to depict the current patterns of practice of stereotactic body radiotherapy (SBRT) for spinal oligometastases.
Methods: The Surveymonkey platform was used to send a 28-items questionnaire focused on demographic, clinical and technical aspects related to SBRT for spinal oligometastases. All the AIRO members were invited to fill the questionnaire.
Background: SARS-CoV-2 mRNA vaccines are highly immunogenic in people living with HIV (PLWH) on effective antiretroviral therapy (ART). However, whether viro-immunologic parameters or other factors affect immune responses to vaccination is debated. This study aimed to develop a machine learning-based model able to predict the humoral response to mRNA vaccines in PLWH and to assess the impact of demographic and clinical variables on antibody production over time.
View Article and Find Full Text PDF