Publications by authors named "G Moncayo"
Article Synopsis
- - The study evaluates the impact of nirsevimab, a newly approved monoclonal antibody, on reducing RSV-related respiratory illnesses in newborns during their first RSV season in the UK.
- - Using a decision-analytic model, the research predicts that universal administration of nirsevimab can prevent nearly 200,000 RSV cases and save around £77.2 million in healthcare costs compared to current treatment options.
- - The analysis suggests that nirsevimab could offer significant health benefits and economic savings, with a potential value of £243 to £274 per quality-adjusted life year (QALY) saved, based on willingness-to-pay thresholds.
Livedoid vasculopathy (LV) is a cutaneous manifestation of several diseases that lead to noninflammatory thrombosis of dermal vessels. We report the case of a 26-year-old female with a 4 years and 8 months-old history of diagnosis of LV and a non-healing ulcer of more than a year of evolution. Because of refractory response to standard care, low-pressure hyperbaric oxygen (LPHBOT) was added to the therapeutic scheme (azathiopine 2.
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- The study aimed to analyze how different components of Early Goal-Directed Therapy (EGDT) and antibiotic use affect patient outcomes, specifically length of stay and mortality in hospitals.
- In a cohort of 884 adult patients with infections and low blood pressure or high lactate levels, researchers found a hospital mortality rate of 17%, with antibiotics administered within the first 3 hours showing a significant 21% reduction in mortality.
- Results indicated that for patients with high lactate levels, not decreasing lactate by at least 10% within 6 hours was linked to increased mortality, highlighting the importance of early antibiotic treatment and lactate management in emergency settings.
Background: Glioblastoma (GBM) is one of the most aggressive human brain tumors, with a median survival of 15-18 months. There is a desperate need to find novel therapeutic targets. Various receptor protein kinases have been identified as potential targets; however, response rates in clinical studies have been somewhat disappointing.
View Article and Find Full Text PDFExpression of the cell-surface glycoprotein MHC class I polypeptide-related sequence A (MICA) is induced in dangerous, abnormal, or "stressed" cells, including cancer cells, virus-infected cells, and rapidly proliferating cells. MICA is recognized by the activating immune cell receptor natural killer group 2D (NKG2D), providing a mechanism by which immune cells can identify and potentially eliminate pathological cells. Immune recognition through NKG2D is implicated in cancer, atherosclerosis, transplant rejection, and inflammatory diseases, such as rheumatoid arthritis.
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