Splenic abscess secondary to penetrating gastric ulcer.

Splenic abscess is a rare disease whose diagnosis is difficult, though the use of modern imaging methods has increased diagnosed cases in recent years. We report a case of splenic abscess whose aetiology is unusual, namely, a gastric ulcer penetrating into the splenic artery and causing arterial thrombosis and septic embolism. Ultrasonography and ultrasound-guided puncture resolved any diagnostic doubt, and subsequent surgery confirmed the diagnosis.

HLA class II favors clearance of HCV infection and progression of the chronic liver damage.

Background/aims: This study was aimed to determine whether host-dependent genetic factors modulate the outcome of HCV infection.

Methods: HLA class II DRB and DQB typing was performed in 184 infected patients and 200 healthy volunteers. Among the patients, 149 subjects had persistent HCV viremia (Group 1) and 35 subjects underwent spontaneous viral clearance (Group 2).

Fatal ulcerative panenteritis following colectomy in a patient with ulcerative colitis.

A 37-year-old man, previously submitted to colectomy for ulcerative pancolitis unresponsive to medical therapy, presented with nausea, vomiting, epigastric pain, and bloody diarrhea. An upper gastrointestinal endoscopy revealed mucosal friability, petechiae, and erosions throughout the duodenum, whereas prestomal ileum showed large ulcers and pseudopolyps. Histologically, a dense inflammation chiefly composed of lymphocytes and plasma cells with few neutrophils was detected.

Metastatic melanoma: endoscopy as aid to earlier in vivo diagnosis of gastrointestinal involvement. A case report.

Autopsy frequently reveals gastrointestinal involvement in patients that have died from melanoma, whereas little evidence of the latter emerges in ante-mortem diagnosis and, even then, largely in connection with emergency situations: obstructions, bleeding or perforation. Moreover, the frequently asymptomatic character of gastrointestinal melanoma explains why it largely eludes detection. The present report concerns a case of metastatic melanoma of the stomach, duodenum and liver, where symptoms were scarcely in evidence, and underlines the usefulness of digestive endoscopy both in the staging of the disease and even more so in follow-up.