Publications by authors named "G Mithieux"
Article Synopsis
- Type 2 diabetes (T2D) and obesity are linked to low levels of natriuretic peptide (NP) and reduced NP guanylyl cyclase receptor-A (GCA) in muscles and fat tissue.
- Research in mice shows that lack of ANP/GCA leads to metabolic issues and prediabetes, causing insulin resistance and poor endurance.
- ANP/GCA is crucial for maintaining mitochondrial function and oxidative capacity in skeletal muscle, suggesting it plays a key role in the development of prediabetes.
Article Synopsis
- The study investigates the role of intestinal gluconeogenesis (IGN) in regulating energy balance and the development of feeding circuits in the hypothalamus, particularly during the neonatal period.
- Researchers induced IGN in newborn mice by overexpressing the enzyme G6pc1 and studied the impact on hypothalamic feeding circuit development and sympathetic innervation of adipose tissues.
- Results showed that inducing IGN at birth led to changes in key hypothalamic circuits and better protection against metabolic issues from a high-fat diet, while later induction had no effect on these parameters.
Article Synopsis
- GSDIa leads to metabolic changes in kidney cells, resembling Warburg-like metabolism, which promotes cell growth and the development of kidney cysts.
- The loss of glucose-6 phosphatase (G6PC1) causes harmful accumulation of glycogen and lipids, leading to kidney inflammation, fibrosis, and dysfunction.
- Treatment with rapamycin showed potential in reducing kidney damage, and lipocalin 2 was identified as an important factor in kidney inflammation and early CKD progression.
Article Synopsis
- Behavioral weight loss programs are effective in reducing health risks and improving outcomes, but long-term data on their impact is limited, prompting this large study with over 10,000 participants to evaluate a specific nutritional and psycho-behavioral rehabilitation program (RNPC).
- The study is conducted across 92 centers in France and will analyze various data points, including health conditions, medication use, and sleep-related measures over a span of two years, with follow-ups lasting up to five years.
- Ethical approval has been obtained, and study findings will be published in peer-reviewed journals and presented at conferences, potentially shaping future research on the RNPC's effectiveness.
Introduction: Protein-enriched diets improve glycemic control in diabetes or emotional behavior in depressive patients. In mice, these benefits depend on intestinal gluconeogenesis activation by di-/tripeptides. Intestinal di-/tripeptides absorption is carried out by the peptide transporter 1, PEPT1.
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