Publications by authors named "G Miserocchi"
Objectives: Gastrointestinal stromal tumors, the most prevalent mesenchymal tumors (80 %) of the gastrointestinal tract, comprise less than 1 % of all gastrointestinal neoplasms and about 5 % of all sarcomas. Despite their rarity, Gastrointestinal stromal tumors present diverse clinical manifestations, anatomic locations, histological subtypes, and prognostic outcomes.
Methods: This scoping review comprehensively explores the epidemiology, clinical characteristics, diagnostic and prognostic modalities, as well as new therapeutic options for Gastrointestinal stromal tumors.
Article Synopsis
- Primary squamous cell carcinoma (SCC) can arise in various body parts, with primary gastric squamous cell carcinoma (GSCC) being particularly rare, exemplified by a case of a 72-year-old woman diagnosed with it.
- Diagnostic imaging, including CT scans and ultrasound-endoscopy, revealed a significant mass at the celiac tripod, leading to further tests confirming poorly differentiated carcinoma with squamous differentiation.
- The study emphasizes the need for well-defined diagnostic criteria for GSCC due to the lack of consensus in current classifications, suggesting that a standardized diagnostic panel might improve accuracy.
The air-blood barrier is well designed to accomplish the matching of gas diffusion with blood flow. This function is achieved by maintaining its thickness at ∼0.5 µm, a feature implying to keep extravascular lung water to the minimum.
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- Adipose tissue, or body fat, is more than just a fat store; it helps in cancer growth by providing energy and sending signals that promote tumor activity.
- Cancer can make fat cells act differently, which creates a cycle that helps the tumor grow even more.
- The review also talks about how being obese can increase cancer risks and how different diets can influence cancer's development and new treatments for it.
Article Synopsis
- Musculoskeletal sarcomas are rare and diverse tumors, making research and treatment challenging for scientists and healthcare providers.
- Traditional methods using mice for xenografting are increasingly limited due to ethical concerns and stricter regulations, leading researchers to seek alternative models like chick embryos and zebrafish.
- These alternative models offer benefits such as cost-effectiveness, ease of tracking tumor growth, and the potential for enhanced drug screening, suggesting that a combination of different models could improve research and understanding of these tumors.