Publications by authors named "G Miscio"
Background: Since the beginning of the anti-COVID-19 vaccination campaign, it has become evident that vaccinated subjects exhibit considerable inter-individual variability in the response to the vaccine that could be partly explained by host genetic factors. A recent study reported that the immune response elicited by the Oxford-AstraZeneca vaccine in individuals from the United Kingdom was influenced by a specific allele of the human leukocyte antigen gene HLA-DQB1.
Methods: We carried out a genome-wide association study to investigate the genetic determinants of the antibody response to the Pfizer-BioNTech vaccine in an Italian cohort of 1351 subjects recruited in three centers.
Article Synopsis
- Notch signaling is crucial for tissue development and affects human osteoclast differentiation, with Notch1 showing conflicting roles in human versus mouse osteoclast formation.
- Our study reveals that active Notch1 signaling blocks the differentiation of human mononuclear CD14 cells into osteoclasts while promoting expansion of specific cell subsets during osteoclastogenesis.
- We found that IL7R is a downstream target of Notch1, highlighting a new interaction that enhances the development of osteoclast progenitors, and showcasing distinct gene expression and signaling pathways involved in this process.
A rhabdoid colorectal tumor (RCT) is a rare cancer with aggressive clinical behavior. Recently, it has been recognized as a distinct disease entity, characterized by genetic alterations in the and Ciliary Rootlet Coiled-Coil (). We here investigate the genetic and immunophenotypic profiling of 21 RCTs using immunohistochemistry and next-generation sequencing.
View Article and Find Full Text PDFBackground: A significant proportion of patients with coronavirus disease 2019 (COVID-19) suffer from delirium during hospitalization. This single-center observational study investigates the occurrence of delirium, the associated risk factors and its impact on in-hospital mortality in an Italian cohort of COVID 19 inpatients.
Methods: Data were collected in the COVID units of a general medical hospital in the South of Italy.
COVID-19 is a viral infection, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and characterized by a complex inflammatory process and clinical immunophenotypes. Nowadays, several alterations of immune response within the respiratory tracts as well as at the level of the peripheral blood have been well documented. Nonetheless, their effects on COVID-19-related cell heterogeneity and disease progression are less defined.
View Article and Find Full Text PDF