Publications by authors named "G Mikhail"

Background: Limited data exist on the impact of polyvascular disease (PolyVD) on clinical outcomes in female patients undergoing transcatheter aortic valve replacement (TAVR). We therefore sought to investigate clinical outcomes in women with versus without PolyVD undergoing TAVR.

Methods: Female participants from the multicentre Women's International Transcatheter Aortic Valve Implantation (WIN-TAVI) registry were categorized based on the presence or absence of PolyVD.

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: Acute ischemic stroke is an uncommon but potentially devastating complication of Transcatheter Aortic Valve Implantation (TAVI). Despite improvements in device technology and procedural techniques, stroke rates have remained stable, with cerebral embolic protection devices demonstrating only limited efficacy to date. Therefore, the management of acute ischemic stroke complicating TAVI (AISCT) remains a key priority.

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Article Synopsis
  • The study investigates the impact of baseline left ventricular ejection fraction (LVEF) on outcomes for women undergoing transcatheter aortic valve implantation (TAVI).
  • Among the 944 patients analyzed, most had preserved LVEF, but those with reduced LVEF experienced a higher incidence of safety issues at 1-year, including all-cause mortality and major vascular complications.
  • Overall, while reduced LVEF did not significantly affect efficacy outcomes, it was linked to a worse safety profile compared to those with preserved or mildly reduced LVEF.
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Transcatheter aortic valve implantation (TAVI) has emerged as a safe and effective treatment for severe aortic stenosis across the spectrum of surgical risk cohorts. Subsequently, the dramatic increase in procedural volume worldwide has placed significant financial and logistical pressures on healthcare institutions, particularly regarding hospital length of stay (LOS), which can adversely affect patient flow. In this review article, we discuss different peri-procedural strategies developed to reduce LOS and facilitate early discharge after TAVI.

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