Publications by authors named "G Mieli-Vergani"

Article Synopsis
  • Researchers studied the impact of mRNA SARS-CoV-2 vaccines on patients with autoimmune liver diseases to see if vaccination worsened their conditions.
  • A total of 49 patients with primary biliary cholangitis (PBC), 35 with autoimmune hepatitis (AIH), and 9 with primary sclerosing cholangitis (PSC) were tested for autoantibodies before and after vaccination, with results indicating higher rates of autoantibody positivity in liver disease patients compared to healthcare workers.
  • Despite some fluctuations in autoantibody levels following vaccination, the study concluded that mRNA vaccines do not cause significant short-term worsening of autoimmunity in these patients.
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Autoimmune hepatitis (AIH) is a severe hepatopathy characterized by hypergammaglobulinemia, presence of serum autoantibodies and histological appearance of interface hepatitis. Liver damage in AIH is initiated by the presentation of a liver autoantigen to uncommitted Th0 lymphocytes, followed by a cascade of effector immune responses culminating with the production of inflammatory cytokines, activation of cytotoxic cells and subsequent hepatocyte injury. B cells actively participate in AIH liver damage by presenting autoantigens to uncommitted T lymphocytes.

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Article Synopsis
  • The Swiss Autoimmune Hepatitis Cohort Study, initiated in 2017, collects clinical data and biological samples from patients of all ages with autoimmune hepatitis across Switzerland, analyzing the first five years of data.
  • A total of 291 patients were enrolled, with a paediatric cohort of 30 (median age 12.5 years) and an adult cohort of 261 (median age 54 years), highlighting variations in demographics and associated health conditions.
  • Most pediatric and adult patients received treatment primarily with corticosteroids, often in combination with other medications, and the follow-up period for the entire cohort averaged 5.2 years.
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Drug-induced liver injury (DILI) can mimic almost all other liver disorders. A phenotype increasingly ascribed to drugs is autoimmune-like hepatitis (ALH). This article summarises the major topics discussed at a joint International Conference held between the Drug-Induced Liver Injury consortium and the International Autoimmune Hepatitis Group.

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