Polarized Light Imaging of the Myoarchitecture in Tetralogy of Fallot in the Perinatal Period.

The pathognomonic feature of tetralogy of Fallot (ToF) is the antero-cephalad deviation of the outlet septum in combination with an abnormal arrangement of the septoparietal trabeculations. The aim of this article was to study perinatal hearts using Polarized Light Imaging (PLI) in order to investigate the deep alignment of cardiomyocytes that bond the different components of the ventricular outflow tracts both together and to the rest of the ventricular mass, thus furthering the classic description of ToF. 10 perinatal hearts with ToF and 10 perinatal hearts with no detectable cardiac anomalies (control) were studied using PLI.

Quantitative comparison of human myocardial fiber orientations derived from DTI and polarized light imaging.

Diffusion tensor imaging (DTI) is a non-invasive technique used to obtain the 3D fiber structure of whole human hearts, for both in vivo and ex vivo cases. However, by essence, DTI does not measure directly the orientations of myocardial fibers. In contrast, polarized light imaging (PLI) allows for physical measurements of fiber orientations, but only for ex vivo case.

Postnatal myocardium remodelling generates inhomogeneity in the architecture of the ventricular mass.

Background: The 3D architecture of the ventricular mass is poorly known, although in vivo imaging techniques show the physiological inhomogeneity of ventricular walls mechanics. Polarized light imaging makes it possible to quantitatively analyse the myosin filament orientation.

Aims: In this paper, we focus on the study the 3D architecture and regional isotropy of myocardial cells.

Study of myocardial cell inhomogeneity of the human heart: Simulation and validation using polarized light imaging.

Purpose: The arrangement or architecture of myocardial cells plays a fundamental role in the heart's function and its change was shown to be directly linked to heart diseases. Inhomogeneity level is an important index of myocardial cell arrangements in the human heart. The authors propose to investigate the inhomogeneity level of myocardial cells using polarized light imaging simulations and experiments.