Publications by authors named "G Mehlhorn"
Article Synopsis
- The study focuses on the diagnostic challenges of colposcopy in women aged 50 and older, particularly those with postmenopausal status and transformation zone type 3 (TZ3), highlighting the role of endocervical curettage (ECC) in diagnosing cervical lesions.
- By analyzing data from colposcopies performed at Erlangen University Hospital between 2016 and 2023, researchers correlated Pap and HPV results with histologic findings from ECC.
- The findings reveal that ECC can effectively detect significant lesions, including high-grade cervical intraepithelial neoplasia (CIN) and invasive carcinoma, even in patients with normal colposcopic results, underscoring its importance in diagnostic procedures.
Post-treatment follow-up in women with CIN3 is mandatory due to relapse in up to 15% of patients within 2 years. Standard follow-up care based on hrHPV-DNA/cytology co-testing has high sensitivity but limited specificity. The aim of our proof-of-concept case-control study was to evaluate the performance of the methylation test GynTect for the detection of recurrent CIN2/3 during follow-up.
View Article and Find Full Text PDFBackground/aim: The global impact of the COVID-19 pandemic resulted in disruptions to healthcare systems throughout the world. The numbers of cytology examinations, human papillomavirus (HPV) tests, and women referred for colposcopy decreased in many countries. There have been no reports on cervical cancer screening in Germany.
View Article and Find Full Text PDF(1) Background: Vaginal intraepithelial neoplasia (VaIN) is a rare premalignant disease caused by persistent human papillomavirus (HPV) infection. Diagnosing VaIN is challenging; abnormal cytology and positive HPV tests are usually the first signs, but published data on their accuracy for detecting it are rare and contradictory. The aim of this study is to compare the results of hrHPV and cytology co-testing with the histological findings of the vagina.
View Article and Find Full Text PDFArticle Synopsis
- * It highlights a study conducted at Erlangen University Hospital, which included 5,594 patients and over 16,000 examinations in their certified dysplasia unit from July 2014 to December 2019.
- * Dysplasia units play a crucial role in managing abnormal screening results and serve as the initial contact for patients with genital issues, successfully meeting quality standards for yearly recertification.