Publications by authors named "G Mechtersheimer"
Article Synopsis
- The PLAG1 gene fusions have been found in some uterine myxoid leiomyosarcomas (M-LMS), but there are cases of PLAG1-rearranged uterine sarcomas that do not resemble M-LMS or show smooth muscle markers.
- A study involving 11 cases of these sarcomas showed diverse features, with patient ages ranging from 34 to 72 years and tumor sizes between 6.5 to 32 cm.
- Follow-up data indicated varying outcomes; while some patients showed no disease evidence, others experienced disease progression or died within a few years, and the tumors displayed significant morphological diversity, including unusual characteristics like hyalinized stroma and adipocytic differentiation
The redirection of T cells has emerged as an attractive therapeutic principle in B cell non-Hodgkin lymphoma (B-NHL). However, a detailed characterization of lymphoma-infiltrating T cells across B-NHL entities is missing. Here we present an in-depth T cell reference map of nodal B-NHL, based on cellular indexing of transcriptomes and epitopes, T cell receptor sequencing, flow cytometry and multiplexed immunofluorescence applied to 101 lymph nodes from patients with diffuse large B cell, mantle cell, follicular or marginal zone lymphoma, and from healthy controls.
View Article and Find Full Text PDFRAD51B-rearranged sarcomas are rare neoplasms that exhibit a heterogeneous morphology. To date, 6 cases have been reported, all involving the uterus, including 4 perivascular epithelioid cell tumors (PEComas) and 2 leiomyosarcomas (LMS). In this study, we describe the morphologic, immunohistochemical, and molecular features of 8 additional sarcomas with RAD51B rearrangement, including the first extrauterine example.
View Article and Find Full Text PDFIntroduction: Low-grade myofibroblastic sarcoma (LGMS) is a rare tumor entity which occurs in the subcutaneous and deep soft tissues; it is less common in the bone with a predilection for the extremities and the head and neck region. As confirming the diagnosis is difficult and treatment strategies are not standardized, we aimed to identify patient and tumor characteristics, and to summarize treatment strategies and their clinical outcomes to guide surgeons.
Methods: Included were full articles reporting patients with histology of LGMS in the extremities, excluding tumors of the trunk.