Publications by authors named "G McMullan"

Article Synopsis
  • Electron cryomicroscopy is a method for determining the structures of most biological molecules but faces challenges like access, preparation, and cost.
  • A newly developed 100 keV instrument improves electron optics, detection, and processing, significantly reducing costs and time for structure determination to just hours.
  • This instrument demonstrated its effectiveness by accurately imaging eleven specimens, ranging from 140 kDa to 2 MDa, using much less data than traditional methods, potentially broadening the scope of structural biology research.
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, the leading cause of antibiotic-associated diarrhoea worldwide, is a genetically diverse species which can metabolise a number of nutrient sources upon colonising a dysbiotic gut environment. Trehalose, a disaccharide sugar consisting of two glucose molecules bonded by an α 1,1-glycosidic bond, has been hypothesised to be involved in the emergence of hypervirulence due to its increased utilisation by the RT027 and RT078 strains. Here, growth in trehalose as the sole carbon source was shown to be non-uniform across representative strains, even though the genes for its metabolism were induced.

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A new species of , a Gram-positive, spore-forming anaerobic group, proposed name sp. nov., was isolated in Northern Ireland from bovine faeces collected in 2016.

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Clostridioides difficile (C. difficile) is an opportunistic pathogen that leads to antibiotic-associated diarrhoea and is a leading cause of morbidity and mortality worldwide. Antibiotic usage is the main risk factor leading to C.

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(basonym ) is a bacterial enteropathogen associated with cases of infection that can result in pseudomembranous colitis, rapid fluid loss, and death. For decades following its isolation, was thought to be a solely nosocomial pathogen, being isolated from individuals undergoing antimicrobial therapy and largely affecting elderly populations. More recently, spores have been identified in the broader environment, including in food-producing animals, soil, and food matrices, in both ready-to-eat foods and meat products.

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