A new clinical index scale for measuring secondary alveolar bone grafting success based on canine eruption.

Objectives: To develop a reproducible, reliable clinical index of alveolar bone grafting (ABG) outcome based on the eruption position of the cleft canine tooth and determine the association between eruption position and radiographic outcome at 6 months post-grafting.

Methods: Children with complete, non-syndromic, unilateral/bilateral cleft lip and palate in the West of Scotland were identified. Post-ABG radiographic outcome (Kindelan index) and canine eruption position in children with a cleft of the alveolus who had undergone ABG were documented.

: regulatory roles, cancer-associated signaling pathway disruptions, and therapeutic potential.

Introduction: () is a crucial post-transcriptional regulator of many mRNA transcripts and noncoding-RNAs, influencing cell proliferation, cancer cell stemness, apoptosis, and immune responses. Its abnormal expression is well-characterized in numerous cancers, establishing it as a significant genomic vulnerability and biomarker in cancer research.

Areas Covered: Here, we summarize 's correlation with poor patient outcomes across numerous cancers and the mechanisms governing 's activity and processing.

Clinical effectiveness of customized versus noncustomized orthodontic appliances: A systematic review.

Objective: To evaluate the clinical effectiveness of treatment with customized compared to noncustomized fixed orthodontic appliances.

Method: A comprehensive search was performed using 13 databases until February 20, 2024. Study eligibility criteria were based on studies that compared orthodontic treatment with customized fixed appliances (labial or lingual) with noncustomized appliances.

Is occlusal contact re-established within 6 months after bonding of a fixed anterior bite plane in adolescents with a Class II division 2 incisor relationship? A randomised controlled trial.

Objective: To determine if re-establishment of occlusal contact was achieved within 6 months after insertion of a fixed anterior bite plane in individuals with Class II division 2 incisor relationship, and to evaluate the occlusal and vertical skeletal changes and acceptance of the intra-oral scanner and bite plane.

Design: Single-centre two-arm parallel group randomised controlled trial with 1:1 allocation to intervention and control groups.

Setting: Dundee Dental Hospital and Research School, UK.

Temporomandibular joint alloplastic replacement failure.

Temporomandibular joint disorders are common, with alloplastic temporomandibular joint replacement (TMJR) being one method of addressing chronic pain and movement limitations that cannot otherwise be managed. Despite this, TMJR has known complications that can lead to failure. We present our experience of managing these cases and review the current evidence on the management and outcomes of alloplastic TMJR failures.