Publications by authors named "G McDermott"
Three-dimensional (3D) models with improved biomimicry are essential to reduce animal experimentation and drive innovation in tissue engineering. In this study, we investigate the use of alginate-based materials as polymeric inks for 3D bioprinting of osteogenic models using human bone marrow stem/stromal cells (hBMSCs). A composite bioink incorporating alginate, nano-hydroxyapatite (nHA), type I collagen (Col) and hBMSCs was developed and for extrusion-based printing.
View Article and Find Full Text PDFRisk of Incident Heart Failure and Heart Failure Subtypes in Patients with Rheumatoid Arthritis.
Arthritis Care Res (Hoboken)
December 2024
Objective: Patients with rheumatoid arthritis (RA) are at increased risk of cardiovascular disease (CVD) including heart failure (HF). However, little is known regarding the relative risks of heart failure subtypes such as HF with preserved (HFpEF) or reduced ejection fraction (HFrEF) in RA compared to non-RA.
Methods: We identified RA patients and matched non-RA comparators among participants consenting to broad research from two large academic centers.
Article Synopsis
- The study sought to identify specific genetic-respiratory disease interactions that increase the risk of developing rheumatoid arthritis (RA).
- Using case-control data from Mass General Brigham and the Mayo Clinic, researchers found significant associations between certain respiratory diseases and RA risk, with particular genetic factors influencing this relationship.
- The results suggest that understanding these genetic-respiratory interactions could lead to more personalized approaches for preventing, diagnosing, and treating RA in the future.
Article Synopsis
- The study aimed to explore if disease-modifying antirheumatic drugs (DMARDs) increase the risk of developing interstitial lung disease (ILD) in patients with rheumatoid arthritis (RA) through a systematic review and meta-analysis of existing research.* -
- From 3,612 studies, 40 were included, covering 486,465 RA patients and 3,928 cases of ILD; overall, no significant link was found between specific DMARDs and ILD in analyzed randomized controlled trials.* -
- However, observational studies indicated that methotrexate (MTX) may reduce the odds of developing ILD, while a large trial comparing tofacitinib with another treatment showed no significant relationship
Rationale: Rheumatoid arthritis (RA) has been implicated in interstitial lung disease (ILD) as majority of studies have been comprised of patients with known RA. However, it remains unclear whether an underlying risk for RA in combination with genetic risk for pulmonary fibrosis is associated with radiological markers of early lung injury and fibrosis in broader population samples.
Objective: Determine whether genetic and serological biomarkers of RA risk in combination with the (rs35705950) risk allele (T) are associated with interstitial lung abnormalities (ILA) on computed tomography (CT) scans.