Publications by authors named "G Mboowa"
Background: Non-malarial febrile illnesses (NMFI) pose significant challenges in HIV-infected children, often leading to severe complications and increased morbidity. While traditional diagnostic approaches focus on specific pathogens, shotgun metagenomic sequencing offers a comprehensive tool to explore the microbial landscape underlying NMFI in this vulnerable population ensuring effective management.
Methods: In this study, we employed shotgun metagenomics to analyse stool samples from HIV-infected children at the Baylor Children's Clinic Uganda presenting with non-malarial febrile illness.
Article Synopsis
- Metagenomics has revolutionized our understanding of microbial communities, especially via wastewater analysis, offering unique opportunities for public health monitoring and tracking antimicrobial resistance in Africa.
- High-throughput sequencing (HTS) allows for direct and cost-effective analysis of wastewater, which can serve as an early warning system for disease outbreaks, particularly in densely populated urban areas.
- Despite its potential, challenges like varying wastewater composition, limited sequencing infrastructure, and socio-political issues hinder implementation; therefore, building local expertise and collaboration is essential for maximizing the benefits of wastewater metagenomics.
Killer-cell immunoglobulin-like receptors (s) are essential components of the innate immune system found on the surfaces of natural killer (NK) cells. The s encoding genes are located on chromosome 19q13.4 and are genetically diverse across populations.
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- Commensal oral Candida species can turn pathogenic in people with weakened immune systems, leading to oropharyngeal candidiasis (OPC) due to various factors.
- The study assessed several enzymatic activities (phospholipase, proteinase, hemolysin, esterase, and coagulase) and biofilm formation in 35 Candida isolates from people living with HIV experiencing OPC.
- Results revealed that most isolates exhibited strong phospholipase and proteinase activities, with significant biofilm formation, while other enzymatic activities were less prevalent.