[Neoplasms and dysplasias of the gallbladder and their relationship with lithiasis. A case-control clinicopathological study].

Background: A strong association has been reported between gallbladder carcinoma, premalignant epithelial or metaplasic inflammatory lesions and cholelithiasis, varying the incidence among different ethnic groups.

Purpose: To determine the frequency of association between such lesions and gallbladder lithiasis.

Material And Methods: We examined histopathologic changes in 1,367 cholecystectomy specimens with (1,096) or without (271) lithiasis and established its frequency of association, correlating with main clinical data.