Publications by authors named "G Martinez-Cortes"
Population expansion, larger, and more homogeneous native American ancestry among Mexican mestizo populations based on 10 X-chromosome STR loci (X-STR decaplex system).
Am J Hum Biol
October 2024
Article Synopsis
- The study aimed to assess genetic diversity and demographic history in Mexican Mestizo populations using X-chromosome STRs (X-STRs), focusing on ancestry and population relationships.
- Researchers analyzed the X-STRs in a sample of Mexican Native Americans and compared their results with various populations, revealing that Mexican Mestizos have more Native American ancestry than previously thought, especially in X-linked genetics.
- Findings indicated a unique admixture process during the Spanish Conquest influenced demographic structure, with population growth observed in most areas, except in regions with higher indigenous ancestry and socioeconomic challenges.
Background: In the gene promoter, there is a repeat polymorphism (TSER) that affects the expression level of the thymidylate synthetase (TS) enzyme involved in the response to some anticancer drugs. The G>C transversion located in the TSER*3R allele decreases the expression level of the TS enzyme avoiding the upstream stimulatory factor (USF-1) binding site. Despite the biomedical impact of the SNP G>C, only TSER has been reported in most worldwide populations.
View Article and Find Full Text PDFCharacterization of 58 STRs and 94 SNPs with the ForenSeq™ DNA signature prep kit in Mexican-Mestizos from the Monterrey city (Northeast, Mexico).
Mol Biol Rep
August 2022
Background: STR allele frequency databases from populations are necessary to take full advantage of the increased power of discrimination offered by massively parallel sequencing (MPS) platforms.
Material And Methods: For this reason, we sequenced 58 STRs (aSTRs, X-STRs, and Y-STRs) and 94 identity informative SNPs (iiSNPs) on 105 Mestizo (admixed) individuals from Monterrey City (Northeast, Mexico), with the Primer Set-A of the ForenSeq™ DNA Signature Prep Kit.
Results: Most of the STR markers were in Hardy Weinberg equilibrium, with a few exceptions.
To evaluate the genetic distribution of the and variants in the gene in Mexican Mestizo (admixed) and Native American groups. We recruited 360 volunteers who were qPCR-genotyped with TaqMan probes. Allele and genotype frequencies are reported.
View Article and Find Full Text PDFBackground: MATE2-K is an efflux transporter protein of organic cation expressed mainly in the kidney and encoded by the SLC47A2 gene. Different variants of this gene have shown an impact on the pharmacokinetics of various drugs, including metformin, which represents one of the most widely used drugs in treating type 2 diabetes. The SLC47A2 gene variants have been scarcely studied in Mexican populations, especially in Native American groups.
View Article and Find Full Text PDF