Dimer Is Not Double: The Unexpected Behavior of Two-Floor Peptide Nanosponge.

Using the framework of an investigation of the stimuli-responsive behavior of peptide assembly on a solid surface, this study on the behavior of a chemisorbed peptide on a gold surface was performed. The studied peptide is a dimeric form of the antimicrobial peptide Trichogin GAIV, which was also modified by substituting the glycine with lysine residues, while the N-terminus octanoyl group was replaced by a lipoic one that was able to bind to the gold surface. In this way, a chemically linked peptide assembly that is pH-responsive was obtained because of the protonation/deprotonation of the sidechains of the Lys residues.

Polyetheretherketone Double Functionalization with Bioactive Peptides Improves Human Osteoblast Response.

In recent years, the demand for orthopedic implants has surged due to increased life expectancy, necessitating the need for materials that better mimic the biomechanical properties of human bone. Traditional metal implants, despite their mechanical superiority and biocompatibility, often face challenges such as mismatched elastic modulus and ion release, leading to complications and implant failures. Polyetheretherketone (PEEK), a semi-crystalline polymer with an aromatic backbone, presents a promising alternative due to its adjustable elastic modulus and compatibility with bone tissue.

Salvage Radiotherapy PSMA PET/CT-guided in Men With PSA Recurrence.

Background/aim: To evaluate the clinical outcome in men with recurrent prostate cancer (PCa) treated by salvage radiotherapy (sRT) prostate-specific membrane antigen positron emission tomography/computed tomography (PSMA PET/CT)-guided.

Patients And Methods: From January 2021 to January 2023, 33 patients who previously underwent definitive/systemic therapy were submitted to sRT PSMA PET/CT-guided for PCa recurrence: 16 (48.5%) on the prostate bed (PB), 12 (36.

Building Surfaces with Controlled Site-Density of Anchored Human Serum Albumin.

Stable and uniform layers of protein molecules at the surface are important to build passive devices as well as active constructs for smart biointerfaces for a large number of biomedical applications. In this context, a strategy to build-up surfaces able to anchor protein molecules on specific and controlled surface sites has been developed. Human serum albumin (HSA) has been chosen as a model protein due to its important antithrombogenic properties and its features in cell response highly valuable for in vivo devices.