Publications by authors named "G Marchetto"
Current cardiac surgery has evolved to include hybrid and minimally invasive settings. In parallel, less invasive techniques have been extended to complex clinical scenarios and may prove even more beneficial in higher-risk patients. However, comorbidities and challenging anatomy still represent limitations to widespread application of this philosophy.
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- HyperCKaemia, or elevated serum creatine kinase (CK), is frequently seen in various myopathies but can also occur in neurological disorders, making diagnosis challenging.
- A case of a 58-year-old man illustrates the complexity, as he had a long history of muscle cramps and high CK levels, and was diagnosed with Charcot-Marie-Tooth disease type 1A through genetic testing.
- Further genetic testing revealed a new variant related to dystrophinopathy, emphasizing the need to thoroughly investigate high CK levels in patients, even those with neurogenic disorders, to ensure proper monitoring for possible myopathy-related complications.
Minimally invasive mitral valve surgery (MIMVS) has been increasingly adopted worldwide as an alternative to conventional sternotomy, especially for young patients. The remarkable results gained by MIMVS have encouraged its application in more complex and fragile patients, such as the elderly, though results in this subgroup remain controversial. It is the aim of this study to assess the postoperative outcomes of patients older than 75 years old undergoing MIMVS, and to compare these results to those of younger patients.
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- A 26-year-old woman with asthma and nasal polyps was diagnosed with eosinophilic granulomatosis with polyangiitis (EGPA) after experiencing acute aortoiliac thrombosis and mitral insufficiency.
- The patient underwent successful treatments including thrombolysis, aortic thromboendarterectomy, and valve replacement, alongside a diagnosis of antineutrophilic cytoplasmic antibody-negative EGPA due to peripheral hypereosinophilia.
- Following treatment with prednisone and mepolizumab, the patient's condition improved, emphasizing the significance of early detection for better outcomes in EGPA cases involving large vessels.
Article Synopsis
- * Patient-specific stem cells, known as iPSCs, are used alongside these organoids to explore the underlying causes of various diseases, especially rare ones, by overcoming issues with sample availability and animal testing.
- * The review highlights techniques for creating these organoids and their application in studying rare neurological, muscular, and skeletal diseases, while also addressing challenges and opportunities for new treatments.