flower is used in traditional medicine for its antioxidant and antibacterial properties, which are attributed to phenolic compounds. These compounds present different grades of associations with the plant matrix (free, esterified, and insoluble). This study aimed to determine which fraction contributes the most to total phenolic and flavonoid contents and bioactive properties.
View Article and Find Full Text PDFPharmacoepidemiol Drug Saf
December 2024
Introduction: Determining lines of therapy (LOT) using real-world data is crucial to inform clinical decisions and support clinical research. Existing rules for determining LOT in patients with metastatic non-small cell lung cancer (mNSCLC) do not incorporate the growing number of targeted therapies used in treatment today. Therefore, we propose rules for determining LOT from real-world data of patients with mNSCLC treated with targeted therapies.
View Article and Find Full Text PDFIntroduction: Characteristics of long-term survivors in EGFR-mutant (EGFRm) NSCLC are not fully understood. This retrospective analysis evaluated a multi-institution cohort of patients with EGFRm NSCLC treated in the pre-osimertinib era and sought to describe characteristics of long-term survivors.
Methods: Clinical characteristics and outcomes were abstracted from the electronic medical records of patients with EGFRm metastatic NSCLC who started first-line therapy before 2015.
Propolis is a complex mixture formed from exudates that bees collect from plants and then mix with beeswax and their own salivary enzymes. Chilean propolis is characterized by the presence of phenolic compounds, which are considered responsible for the biological activities. The endemic species (Ruiz and Pav.
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