Publications by authors named "G Mani Subramaniam"
Article Synopsis
- * Among 716 adolescents analyzed, the rates of nonmedical use of prescription medications varied significantly across the screening tools, with the S2BI tool reporting the highest rate (8.5%).
- * The findings suggest that the misuse of prescription medications might be more common than previously thought, but the study also cautions that some results may be inaccurate and that refining screening questions could help clarify these behaviors.
Article Synopsis
- Identifying new adjuvants to make vaccines more effective is crucial, with one promising method being the use of TLR9 agonists like CpG ODNs to boost dendritic cell function.
- D-15800, a specific D-peptide isomer, has been found to better stimulate the production of the immune response mediator IL-12p70 and promote differentiation of monocytes into dendritic cells compared to its L-isomer counterpart.
- When combined with TLR9 agonists, D-15800 not only activates immune cells like CD4 T and natural killer cells but also enhances interferon-alpha production, indicating it could significantly improve vaccine outcomes.
Article Synopsis
- Metabolic dysfunction-associated steatohepatitis (MASH) is a serious liver condition with limited treatment options and relies on manual biopsies for assessment, which often shows high variability among readers.
- A new artificial intelligence (AI) system, AIM-MASH, has been developed and validated across multiple sites to assist pathologists in scoring liver biopsies related to MASH, showing high reliability and consistency compared to traditional methods.
- AIM-MASH significantly improved the accuracy of assessing key factors like inflammation and MASH resolution when used by expert pathologists, suggesting it can reduce variability and enhance the evaluation of new treatments in MASH clinical trials.
Objective: To test whether pediatrician training leads to provider utilization of stimulant diversion prevention strategies as reported by adolescent patients with ADHD.
Methods: Pediatric practices received a stimulant diversion prevention workshop (SDP) or continued treatment-as-usual (TAU) in a cluster-randomized controlled trial. Surveys were completed by 341 stimulant-treated patients at baseline and three follow-up assessments.