Publications by authors named "G Malerba"
Previous studies in sports science suggested that regular exercise has a positive impact on human health. However, the effects of endurance sports and their underlying mechanisms are still not completely understood. One of the main debates regards the modulation of immune dynamics in high-intensity exercise.
View Article and Find Full Text PDFBackground/objectives: microRNAs (miRNAs) and circular RNA (circRNAs) show a close interconnection in the control of fundamental functions, such as cell proliferation and tumor development. A full understanding of this complex and interconnected network is essential for better understanding the mechanisms underlying cancer progression. Hsa_circ_0079593 is a circRNA highly expressed in melanoma and is associated with increased metastasis and progression of malignancy, whereas miR516b-5p is a microRNA whose expression is lower in several tumor types, including melanoma; its overexpression inhibits cell proliferation, migration, and invasion.
View Article and Find Full Text PDFBackground: Robot-Assisted Gait Rehabilitation (RAGR) is an established clinical practice to encourage neuroplasticity in patients with neuromotor disorders. Nevertheless, tasks repetition imposed by robots may induce boredom, affecting clinical outcomes. Thus, quantitative assessment of engagement towards rehabilitation using physiological data and subjective evaluations is increasingly becoming vital.
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- Kidney stone disease (KSD) is a growing global health issue, with around 30% of children and 1-5% of adults potentially having monogenic variants, yet genetic testing remains underutilized due to a lack of awareness and perceived benefits.
- A study of 1675 patients showed that genetic testing yielded a positive result in about 20% overall, with a higher likelihood (26%) in pediatric patients compared to adults (8%), indicating the importance of age in diagnosis.
- The most common genetic condition found was cystinuria, and the overall diagnostic yield decreased notably when excluding cases identifiable through other tests, highlighting the need for more awareness and application of genetic testing in KSD.
Article Synopsis
- Hallux valgus is a common foot deformity that causes pain and disability, with the minimally invasive Chevron and Akin osteotomies (MICA) being a popular surgical option to treat it.
- A systematic review was conducted following strict PRISMA guidelines, analyzing studies on MICA for severe hallux valgus involving 582 patients and focusing on improvement in function and quality of life.
- The results suggest that MICA is effective, showing significant improvements in radiological measurements (like angles) and high patient satisfaction, despite a limited number of existing studies.